Article: Nicotinamide Riboside Slows Biological Aging by 2.5 Years: Clinical Findings

Jul 21, 2026 Clinical Muscle Health

Nicotinamide Riboside Slows Biological Aging by 2.5 Years: Clinical Findings

Objectives

To investigate the effects of NR supplementation and high-intensity interval training on skeletal muscle epigenetic aging, as assessed by DNA methylation–based epigenetic clocks and measures of epigenetic age acceleration.

Journal

Aging Cell

Key Outcomes

NR supplementation slowed biological aging in three of the seven clocks, including a roughly 2.5-year reduction in age acceleration on the muscle-specific MEAT clock.
Exercise produced different, clock-dependent changes, including higher DunedinPACE estimates.

Duration

NR: 5 months
Exercise: 4 or 6 weeks

Dose

NR: 1000 mg
Exercise: High-intensity interval training, three times per week

Study Design

Exploratory analysis of three independent cohorts: a nonrandomized, open-label, parallel-assignment study of identical twin pairs with BMI discordance (one leaner, one heavier), with 30 participants providing paired muscle samples, and two exercise cohorts of 39 and 37 participants.

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