Combined Metabolic Activators Reduce Liver Fat by Boosting Mitochondria: Preclinical Findings

SynopsisWith NAFLD increasing globally and no approved treatments, researchers tested a combination of metabolic activators (including NAD+ precursor nicotinamide riboside, antioxidants, and amino ...

Metabolic Cofactors Including Nicotinamide Riboside Improves Non-Alcoholic Fatty Liver Disease: Preclinical Findings

SynopsisNon-alcoholic fatty liver disease (NAFLD) is a common liver condition linked to obesity and metabolic problems, but no effective treatment exists. Researchers tested a combination of metabo...

Nicotinamide Riboside Increased Liver Regeneration by Enhancing Mitochondrial Functions: Preclinical Findings

Synopsis The liver’s ability to regenerate after injury or surgery is vital for survival, but the metabolic mechanisms behind this process are not fully understood. This study found that losing th...

Nicotinamide Riboside Supplementation Increases Plasma Levels of the Exercise Hormone Fndc5/Irisin: Clinical Findings

Objectives To investigate the effects of NAD-boosting therapy via NR on Fndc5/irisin levels in humans and its potential role in the development and progression of nonalcoholic fatty liver disease ...

Nicotinamide Riboside Protects the Liver from Alcohol-Induced Damage: Preclinical Findings

Synopsis Alcoholic liver disease (ALD) is a major consequence of long-term alcohol use, yet safe and effective treatments are still limited. This study found that nicotinamide riboside (NR), a vit...

Adult Zebrafish Provide an In Vivo Platform for Evaluating Drug Responses in Ethanol-Induced Acute Hepatic Injury: Preclinical FIndings

Synopsis Chronic alcohol use can damage the liver, but effective treatments are limited. Researchers developed an adult zebrafish model to quickly test drugs for alcohol-induced liver injury. Expo...

Nicotinamide Riboside Supplementation Combined with Metabolic Cofactors Shows Promise for NAFLD: Clinical Findings

Objectives To assess the tolerability and metabolic effects of combined supplementation with combined metabolic activators (CMA), L-serine, NAC, nicotinamide riboside, and L-carnitine in healthy h...

Nicotinamide Riboside Supplementation with Metabolic Cofactors Reduces Liver Fat in NAFLD Patients: Clinical Findings

Objectives To determine if combined metabolic activator supplementation (CMA) will reduce hepatic fat in nonalcoholic fatty liver disease (NAFLD) patients. Journal Molecular Systems Biology Key O...

Study of Nicotinamide Riboside's Properties and Degradation Kinetics: Preclinical Findings

Synopsis Nicotinamide riboside (NR), a form of vitamin B3 and a precursor to NAD+, shows promise as a therapeutic compound for aging. However, little is known about its physical and chemical prope...

Effects of High-Dose Nicotinamide Riboside on White Fat Tissue Function and Insulin Sensitivity: Preclinical Findings

Synopsis Nicotinamide riboside (NR) is a vitamin that helps produce NAD+, a key molecule for metabolism. Although reports of negative effects from high doses of NR are rare, this study examined ho...

Nicotinamide Riboside Protects Against Diet-Induced Liver Injury: Preclinical Findings

Synopsis Nicotinamide riboside (NR), a precursor to NAD+, helps prevent metabolic and age-related disorders in mice, but the role of naturally occurring NR metabolism is less understood. Researche...

L-Carnitine and Nicotinamide Riboside Reduce Obesity and Liver Fat: Preclinical Findings

Synopsis Obesity and fat buildup in the liver can lead to non-alcoholic fatty liver disease (NAFLD). This study tested whether L-carnitine (LC) and nicotinamide riboside (NR), which support fat me...

Nicotinamide Riboside Supplementation Reverses Aging-Associated NAFLD: Preclinical Findings

Synopsis Aging increases the risk of non-alcoholic fatty liver disease (NAFLD), but the mechanisms are not fully clear. This study tested whether nicotinamide riboside (NR), a precursor to NAD+, c...

Nicotinamide Riboside Regulates Inflammation and Improves Mitochondrial Function in Liver Cells: Preclinical Findings

Synopsis This study examined the effects of nicotinamide riboside (NR), a vitamin B3 derivative, on liver cells. Mouse hepatocytes were treated with palmitic acid to mimic fat-induced stress, then...

High-Dose Nicotinamide Riboside Supplementation Is Safe and Effective: Clinical Findings

Objectives To test the safety of NR supplementation and its potential to improve insulin sensitivity and other metabolic parameters in obese, insulin-resistant men. Journal The American Journal of...

Nicotinamide Riboside Restores NAD+ Levels and Improves Mitochondrial Function in Skeletal Muscle Cells: Preclinical Findings

Synopsis Nicotinamide phosphoribosyltransferase (NAMPT) helps produce NAD+, which is essential for mitochondrial function and energy balance in skeletal muscle cells. Using gene techniques to redu...

Nicotinamide Riboside Protects Against Alcohol-Induced Fatty Liver: Preclinical Findings

Synopsis Scientists have discovered that blocking a key enzyme that consumes cellular energy may help protect the liver from alcohol-related damage. The enzyme, called poly(ADP-ribose) polymerase ...

Nicotinamide Riboside Protects Against Liver Toxicity: Preclinical Findings

Synopsis This study looked at the role of the mitochondrial enzyme MNADK, which makes NADP from NAD+, in liver health. Mice lacking MNADK had higher levels of certain amino acids and carnitines, a...

Purple Sweet Potato Anthocyanins and Nicotinamide Riboside Increase NAD+ Levels and Reduce Liver Inflammation: Preclinical Findings

Synopsis Purple sweet potato color (PSPC), a natural compound from purple sweet potatoes, can help protect the liver from damage caused by a high-fat diet. In mice fed a high-fat diet, PSPC reduce...

Nicotinamide Riboside Kinases Mediate NMN and NR Metabolism in Muscle Cells: Preclinical Findings

Synopsis Increasing NAD+ levels may help protect muscles from age-related decline. This study examined how skeletal muscle cells make NAD+ from precursors nicotinamide mononucleotide (NMN) and nic...