Nicotinamide Riboside Prevents and Reverses Chemotherapy-Induced Peripheral Neuropathy: Preclinical Findings

Synopsis Damage to sensory nerves can cause peripheral neuropathy after chemotherapy. Increasing levels of nicotinamide adenine dinucleotide (NAD+) can protect nerves from injury. This study teste...

Nicotinamide Riboside Decreased DNA Damage in Liver Cells: Preclinical Findings

Synopsis Hepatocellular carcinoma (HCC) is a fast-growing liver cancer, but its exact origin has been unclear. Using human data and mouse models, researchers found that HCC starts mainly from live...

Altered NAD+ and Glutathione Metabolism in Fatty Liver Disease: Preclinical Findings

SynopsisIn patients with non-alcoholic fatty liver disease (NAFLD), researchers identified altered liver metabolism, specifically increased demand for NAD+ and glutathione (GSH), a key antioxidant....

Nicotinamide Riboside Enhances Liver Regeneration: Preclinical Findings

SynopsisThe regenerative capacity of the liver is essential for recovery from surgical resection or injuries induced by trauma or toxins. During liver regeneration, the concentration of nicotinamid...

Nicotinamide Riboside Reduces Liver Inflammation and DNA Damage: Preclinical Findings

Synopsis Obesity increases the risk of liver cancer (hepatocellular carcinoma, HCC), but the exact mechanisms were unclear. This study found that a liver protein called URI links excess nutrients ...

Nicotinamide Riboside Reverses Age-Related Fatty Liver Disease: Preclinical Findings

Synopsis Aging is a major risk factor for non-alcoholic fatty liver disease (NAFLD), but the biological link between the two has remained unclear. This study shows that declining levels of nicotin...

Increasing NAD+ with Nicotinamide Riboside Prevents Liver Cancer Driven by URI: Preclinical Findings

Synopsis The molecular causes of liver cancer (hepatocellular carcinoma, HCC) are not fully understood. This study used genetically modified mice to show that when liver cells produce too much of ...