,%20a%20natural%20compound%20from%20purple%20sweet%20potatoes,%20can%20help%20protect%20the%20liver%20from%20damage%20caused%20by%20a%20high-fat%20diet.%20In%20mice%20fed%20a%20high-fat%20diet,%20PSPC%20reduce...){kind=link}
Purple Sweet Potato Anthocyanins and Nicotinamide Riboside Increase NAD+ Levels and Reduce Liver Inflammation: Preclinical Findings
Synopsis
Purple sweet potato color (PSPC), a natural compound from purple sweet potatoes, can help protect the liver from damage caused by a high-fat diet. In mice fed a high-fat diet, PSPC reduced obesity, liver injury, and oxidative stress. It worked by increasing NAD+ levels, similar to the effect of nicotinamide riboside (NR), a known NAD+ booster, which helped lower stress in the cell’s endoplasmic reticulum (ER). PSPC also blocked key inflammation pathways (NF-κB, NOD1/2) and prevented activation of the NLRP3 inflammasome, a trigger for inflammation. Overall, PSPC reduced liver inflammation and damage by boosting NAD+ and calming the immune response.
Journal
Molecules