Article: Nicotinamide Riboside Protects Against Alcohol-Induced Fatty Liver: Preclinical Findings

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Liver Disease Liver Health Metabolic Health Preclinical

Nicotinamide Riboside Protects Against Alcohol-Induced Fatty Liver: Preclinical Findings

Synopsis

Scientists have discovered that blocking a key enzyme that consumes cellular energy may help protect the liver from alcohol-related damage. The enzyme, called poly(ADP-ribose) polymerase (PARP), uses large amounts of NAD+, a molecule essential for metabolism and energy production. In a study using mice and liver cells, researchers found that inhibiting PARP activity with the compound PJ34 prevented the buildup of fat in liver cells—a hallmark of alcoholic fatty liver disease (AFLD). Mice treated with PJ34 showed lower triglyceride levels, improved liver metabolism, and higher NAD+ content. The team also tested nicotinamide riboside (NR), a form of vitamin B3 that boosts NAD+ levels, and found that it produced similar benefits by reducing liver fat accumulation. These findings suggest that targeting PARP or enhancing NAD+ metabolism could be a novel strategy to treat or prevent alcohol-induced fatty liver disease, a growing global health concern.

Journal

Journal of Pharmacology and Experimental Therapeutics

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