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Nicotinamide Riboside Supplementation Increases Blood NAD+ Levels in Healthy Humans: Clinical Findings
Objectives
To determine the human pharmacokinetics of NR supplementation and its effect on whole blood nicotinamide adenine dinucleotide (NAD+) levels.
Journal
PLoS ONE
Key Outcomes
- NR supplementation significantly increased blood NAD+ concentrations between baseline and Day 9. On average, NAD+ levels increased 2-fold.
- No significant changes were observed in blood pressure, body temperature, body weight, white blood cell count, lactate dehydrogenase (LDH), or aspartate aminotransferase (AST).
Duration
9 days
Dose
2000 mg
Study Design
Non-randomized, open-label study in 8 healthy men and women