Article: Nicotinamide Riboside Supplementation Increases Blood NAD+ Levels in Healthy Humans: Clinical Findings

Dec 6, 2017 Clinical Pharmacokinetic/Safety

Nicotinamide Riboside Supplementation Increases Blood NAD+ Levels in Healthy Humans: Clinical Findings

Objectives

To determine the human pharmacokinetics of NR supplementation and its effect on whole blood nicotinamide adenine dinucleotide (NAD+) levels.

Journal

PLoS ONE

Key Outcomes

NR supplementation significantly increased blood NAD+ concentrations between baseline and Day 9. On average, NAD+ levels increased 2-fold.
No significant changes were observed in blood pressure, body temperature, body weight, white blood cell count, lactate dehydrogenase (LDH), or aspartate aminotransferase (AST).

Duration

9 days

Dose

2000 mg

Study Design

Non-randomized, open-label study in 8 healthy men and women

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