Article: Nicotinamide Riboside Supplementation Increases Blood NAD+ Levels in Healthy Humans: Clinical Findings

Clinical Pharmacokinetic/Safety

Nicotinamide Riboside Supplementation Increases Blood NAD+ Levels in Healthy Humans: Clinical Findings

Objectives

To determine the human pharmacokinetics of NR supplementation and its effect on whole blood nicotinamide adenine dinucleotide (NAD+) levels.

Journal

PLoS ONE

Key Outcomes

NR supplementation significantly increased blood NAD+ concentrations between baseline and Day 9. On average, NAD+ levels increased 2-fold.
No significant changes were observed in blood pressure, body temperature, body weight, white blood cell count, lactate dehydrogenase (LDH), or aspartate aminotransferase (AST).

Duration

9 days

Dose

2000 mg

Study Design

Non-randomized, open-label study in 8 healthy men and women

See Published Study

Clinical

Nicotinamide Riboside Supplementation Is Orally Bioavailable in Both Mice and Humans: Clinical Findings

Objectives To determine the time and dose-dependent effects of NR supplementation on blood NAD+ metabolism in humans. Journal Nature Communications Key Outcomes Single oral doses of NR significan...

Cardiovascular Health

Nicotinamide Riboside Supplementation Safely Boosts NAD+ in Middle-Aged and Older Adults: Clinical Findings

Objectives To assess the tolerability and efficacy of chronic NR supplementation on increasing NAD+ levels in healthy middle-aged and older adults. Journal Nature Communications Key Outcomes NR ...