Article: Nicotinamide Riboside Supplementation Increases NAD+ Levels in Humans: Clinical Findings

Clinical Pharmacokinetic/Safety

Nicotinamide Riboside Supplementation Increases NAD+ Levels in Humans: Clinical Findings

Objectives

To evaluate the safety and efficiacy of NR supplementation in overweight, but otherwise healthy men and women.

Journal

Scientific Reports

Key Outcomes

NR supplementation significantly and dose-dependently increased whole blood NAD+ levels by 22%, 51%, and 142%, respectively, within two weeks. These levels were maintained throughout the remainder of the study.

Duration

8 weeks

Dose

100 mg
300 mg
1000 mg

Study Design

Randomized, double-blind, placebo-controlled, parallel assignment study in 140 overweight, but otherwise healthy men and women

See Published Study

Clinical

High-Dose Nicotinamide Riboside Supplementation Is Safe and Effective: Clinical Findings

Objectives To test the safety of NR supplementation and its potential to improve insulin sensitivity and other metabolic parameters in obese, insulin-resistant men. Journal The American Journal of...