S-Adenosylmethionine and Nicotinamide Riboside Supplementation Improves Fatigue and Stabilizes Vision in PRPS1 Deficiency: Case Report

Objectives To evaluate the impact of S-Adenosylmethionine (SAMe) and NR supplementation on the clinical symptoms of PRPS1 deficiency, specifically focusing on fatigue, cognitive decline, and visio...

Nicotinamide Riboside Reduces Inflammation in Retinal Degeneration: Preclinical Findings

Synopsis Bright light exposure triggers mitochondrial damage in the retina, releasing double-stranded DNA that activates the cGAS-STING inflammatory pathway and drives microglial pyroptosis, accel...

Nicotinamide Riboside Protects Retinal Ganglion Cells: Preclinical Findings

Synopsis Glaucoma causes vision loss by damaging retinal ganglion cells (RGCs)—the neurons that carry visual information to the brain. One key cause of this damage is glutamate excitotoxicity, whe...

Effects of Nicotinamide Riboside on Hearing: Preclinical Findings

Synopsis This study examined how repeated high-dose intravenous nicotinamide riboside (NR)—a vitamin B3–derived NAD+ booster—affects hearing in Wistar rats. Researchers measured the activity of bo...

Nicotinamide Riboside Prevents Chemotherapy-Induced Peripheral Neuropathy: Preclinical Findings

Synopsis Paclitaxel (PTX) is a widely used chemotherapy drug for cancers such as breast, lung, and ovarian cancer, but one of its major side effects is chemotherapy-induced peripheral neuropathy (...

Nicotinamide Riboside Preserves Retinal Cells and Mitochondrial Function in Glucocorticoid-Induced Glaucomae: Preclinical Findings

SynopsisGlucocorticoid-induced glaucoma (GIG) is a common side effect of steroid use that can cause blindness by damaging the eye's trabecular meshwork (TM), raising eye pressure, and killing retin...

Nicotinamide Riboside Mitigates Oxidative Damage and Fibrosis in Trabecular Meshwork Cells: Preclinical Findings

Synopsis Glaucoma is a leading cause of irreversible blindness, often caused by dysfunction and scarring in the trabecular meshwork (TM)—the eye tissue that regulates fluid drainage and intraocula...

Nicotinamide Riboside Restores NAD+ Levels and Improves Metabolism in Diastolic Heart Failure: Preclinical Findings

Synopsis Heart failure with left ventricular diastolic dysfunction is a growing health problem worldwide. This study looked at levels of NAD+, a key metabolic cofactor, in the hearts of patients w...

Nicotinamide Riboside Protects Retinal Nerve Cells in Glaucoma: Preclinical Findings

SynopsisGlaucoma causes progressive retinal ganglion cell (RGC) degeneration and vision loss, often associated with elevated intraocular pressure (IOP). This study tested whether oral administratio...

Nicotinamide Riboside Prevents Age-Related Hearing Loss: Preclinical Findings

SynopsisAge‐related hearing loss (ARHL) is the most common sensory disability associated with human aging. Yet, there are no approved measures for preventing or treating this debilitating condition...

Nicotinamide Riboside Supplementation Partially Restores Sense of Smell in Aging: Preclinical Findings

SynopsisLoss of smell is an early and common feature of both aging and neurodegenerative diseases such as Alzheimer's and Parkinson's. This study investigated behavioral and molecular changes in th...

Nicotinamide Riboside Enhances Mitochondrial Protection to Prevent Hearing Loss: Preclinical Findings

Synopsis Damage from oxidative stress is a major cause of hearing loss, particularly through injury to inner hair cell (IHC) synapses, which connect sensory cells to the auditory nerve. This study...

NR and NMN Restore Meibomian Gland Function and Tear Health: Preclinical Findings

Synopsis This study found that increasing NAD+ levels in the eye can help reverse age-related meibomian gland dysfunction, a major cause of dry eye disease in older adults. The meibomian glands, l...

Nicotinamide Riboside Reduces Chemotherapy-Induced Eye and Body Hypersensitivity: Preclinical Findings

SynopsisChemotherapy often causes dry eye and nerve pain, which may be due to nerve damage. This study treated rats given the chemotherapy drug paclitaxel with nicotinamide riboside (NR). Paclitaxe...

Nicotinamide Riboside Treatment Protects Retinal Cells in Mice: Preclinical Findings

SynopsisGlaucoma often involves death of retinal ganglion cells (RGCs), partly caused by high eye pressure (IOP). But even when IOP is controlled, the disease can still worsen. So, it's important t...

Nicotinamide Riboside Protects Retinal Cells by Supporting Mitochondrial Health: Preclinical Findings

Synopsis Retinal degeneration diseases (RDDs), such as macular degeneration and retinitis pigmentosa, lead to the gradual loss of light-sensing cells in the eye, often caused by oxidative stress a...

Nicotinamide Riboside Protects Lens Cells from Oxidative Stress: Preclinical Findings

Synopsis Researchers found that nicotinamide riboside (NR), a vitamin B3 derivative and NAD+ precursor, can protect eye lens cells from oxidative stress, one of the main causes of cataracts. In la...

NAD+ Precursors Improve Corneal Wound Healing and Nerve Regeneration in Diabetes: Preclinical Findings

Synopsis Nicotinamide adenine dinucleotide (NAD+) is a vital molecule that supports energy metabolism, cell repair, and tissue regeneration. In diabetes, chronically high blood sugar disrupts thes...

Nicotinamide Riboside Protects Optic Nerve from Degeneration: Preclinical Findings

Synopsis Nicotinamide riboside (NR), a precursor to NAD+, protects optic nerve axons from damage caused by tumor necrosis factor (TNF). In rats, NR reduced axon loss, improved autophagy markers (i...

Nicotinamide Riboside Protects Against Light-Induced Retinal Degeneration: Preclinical Findings

SynopsisRetinal diseases cause a decline in nicotinamide adenine dinucleotide (NAD+), a vital coenzyme for cellular energy and biosynthesis, which may contribute to retinal damage. This study teste...