SARM1 Drives Nerve Damage Following Inflammation and Cell Death Signals: Preclinical Findings

SynopsisNeuroinflammation and a type of cell death called necroptosis play big roles in neurodegenerative diseases, often starting with damage to nerve fibers called axons. SARM1 is a key enzyme th...

Nicotinamide Riboside Protects Against Noise-Induced Hearing Loss: Preclinical Findings

Synopsis Noise exposure can damage hearing by reducing the number of ribbon synapses in the inner ear, which are crucial for transmitting sound signals. In mice, temporary noise exposure caused a ...

Nicotinamide and Nicotinamide Riboside Induce Rapid Differentiation and Function in Retinal Pigment Epithelial Cells: Preclinical Findings

Synopsis Human retinal pigment epithelial (RPE) cells, especially the ARPE-19 cell line, are commonly used in eye and general epithelial cell research. While they are convenient and consistent, th...

NAD+ Metabolism: Energy Production, Signaling Pathways, and Therapeutic Potential: Review

SynopsisVitamin B3's active forms, NAD+ and NADP+, are essential for energy metabolism, cell protection, and biosynthesis. Modern research shows that fluctuations in NAD+ metabolism activate signal...

SIRT1 Activators Like Nicotinamide Riboside Prevent Neuron Damage in Mouse Model of Multiple Sclerosis: Preclinical Findings

Synopsis Axonal damage and neuron loss contribute to permanent vision loss and neurological disability in optic neuritis and multiple sclerosis (MS). Current treatments mainly target inflammation ...