Genetically Encoded Sensors Measure NAD+/NADH Levels in Cell and Mitochondria Compartments: Preclinical Findings

SynopsisThe balance between oxidized (NAD+) and reduced (NADH) forms of NAD inside cells controls energy and antioxidant status. This ratio differs between mitochondria and cytosol and is important...

Genetic Background Influences Nicotinamide Riboside Response in Barth Syndrome: Preclinical Findings

SynopsisBarth Syndrome is a rare genetic disorder caused by mutations in the TAFAZZIN (TAZ) gene, which affects mitochondrial function by disrupting cardiolipin remodeling. While clinical trials ar...

A New Bioluminescent Probe to Monitor Mitochondrial Health Over Time: Preclinical Findings

SynopsisMitochondrial membrane potential (ΔΨm) is a key indicator of mitochondrial health and is involved in diseases like diabetes, cancer, Alzheimer’s, and Parkinson’s. This study introduces a ne...

Nicotinamide Riboside Protects Heart Function in Dilated Cardiomyopathy: Preclinical Findings

Synopsis In chronic heart failure, the heart’s energy metabolism is severely impaired. NAD+ is a key molecule that helps cells produce energy and respond to stress, making it an important focus in...

In Ovo Nicotinamide Riboside Injection Improves Broiler Chicken Muscle Growth: Preclinical Findings

Synopsis This study examined how nicotinamide riboside (NR) affects the development and growth of the pectoralis major muscle (PM) in broiler chickens. Fertilized eggs were injected on day 10 of i...

CD38 Inhibitor Reverses Age-Related NAD+ Decline and Metabolic Dysfunction: Preclinical Findings

Synopsis Aging is characterized by the development of metabolic dysfunction and frailty. Recent studies show that a reduction in nicotinamide adenine dinucleotide (NAD+) is a key factor for the de...

Role of NAD+ in Aging and Disease: Review

SynopsisNAD+ is a key coenzyme for many physiological reactions, particularly those supporting mitochondrial function. Its decline with aging contributes to chronic conditions like cognitive declin...

Modulating NAD+ Metabolism from Preclinical to Clinical Application: Review

SynopsisFirst discovered in the early 1900s, nicotinamide adenine dinucleotide (NAD+) was once seen only as a helper in energy reactions but is now known to be essential for many regulatory protein...