Nicotinamide Riboside and Nicotinamide Mononucleotide Protect Against Kidney Injury: Preclinical Findings

Synopsis This study uncovered how NAD+ deficiency contributes to kidney disease by damaging mitochondria and triggering inflammation. Through metabolic analysis of human kidney samples, researcher...

Nicotinamide Riboside Maintains Mitochondrial Health in Intervertebral Disc Degeneration: Preclinical Findings

Synopsis This study explored how the mitochondrial unfolded protein response (UPRmt) protects cells in the intervertebral disc from damage by activating mitophagy, the process that clears defectiv...

Mitochondrial PARP1 Regulates Mitochondrial DNA and Aging: Preclinical Findings

Synopsis Scientists have discovered that the enzyme PARP1, known for repairing DNA in the cell nucleus, is also active inside mitochondria, where it helps control mitochondrial DNA (mtDNA). Using ...

Mitochondrial Targeting Inhibits Breast Cancer Stem Cells: Preclinical Findings

SynopsisMitochondria are vital cell components that generate energy, build essential molecules, and support cell signaling. In cancer, mitochondria often adapt to fuel tumor growth by supplying the...

Nicotinamide Riboside Improves Mitochondrial Function and Exercise Ability in ANT1-Deficiency: Preclinical Findings

SynopsisMitochondrial disorders are often characterized by muscle weakness and fatigue. Mutations in the heart-muscle adenine nucleotide translocator isoform 1 (ANT1) (or ANT1-deficiency) of both h...

Selective Mitochondrial Inheritance Links Metabolism to Cell Fate: Preclinical Findings

Synopsis This study discovered that the age of mitochondria—the cell’s energy-producing structures—plays a major role in determining how stem cells divide and develop. In epithelial stem-like cell...

Genetically Encoded Sensors Measure NAD+/NADH Levels in Cell and Mitochondria Compartments: Preclinical Findings

SynopsisThe balance between oxidized (NAD+) and reduced (NADH) forms of NAD inside cells controls energy and antioxidant status. This ratio differs between mitochondria and cytosol and is important...

Mitophagy Enhancers, Including Nicotinamide Riboside, Protect Neurons from Tau-Induced Damage in Alzheimer’s Disease: Preclinical Findings

Synopsis In Alzheimer’s disease (AD), abnormal tau proteins damage mitochondria and synapses, leading to impaired energy production and neuron loss. In mouse hippocampal neurons expressing mutant ...

Nicotinamide Riboside Prevents Liver Injury and Restores Mitochondrial Function: Preclinical Findings

SynopsisNAMPT is an enzyme that helps make NAD+. Since low liver NAD+ is linked to fatty liver disease, scientists removed NAMPT specifically from liver cells in mice to see the effect. These mice ...

Nicotinamide Riboside and Metformin Restore Mitochondrial Function: Preclinical Findings

SynopsisMitophagy is the process cells use to clear damaged mitochondria, keeping cells healthy. Defects in this process are linked to neurodegenerative diseases. Using stem cell–derived brain cell...

Unstable NAD+ Metabolism Leads to Impaired Heart Mitochondrial Function: Preclinical Findings

SynopsisPoly(ADP-ribose) polymerase (PARP) enzymes repair DNA but use NAD+ as fuel. Excessive DNA damage in heart cell mitochondria can overactivate PARP, depleting NAD+ and impairing mitochondrial...

Nicotinamide Riboside Rejuvenates Aged Hematopoietic Stem Cells and Improves Regeneration: Preclinical Findings

SynopsisWith age, hematopoietic stem cells (HSCs) lose their ability to regenerate and remain quiescent, leading to an expanded stem cell pool that can cause blood disorders. Researchers found that...

Nicotinamide Riboside Restores Mitochondrial Function and Improves Heart Failure with Preserved Ejection Fraction: Preclinical Findings

SynopsisHeart Failure with Preserved Ejection Fraction (HFpEF) is a serious heart condition without effective treatments. In a mouse model of HFpEF, researchers found impaired mitochondrial fatty a...

Nicotinamide Riboside Improves Mitophagy and Reduces Neuroinflammation in Ataxia Telangiectasia: Preclinical Findings

SynopsisIn the premature aging disease ataxia telangiectasia (A-T), cells show mitochondrial dysfunction and a senescence state that causes inflammation (SASP). This is linked to buildup of damaged...

Nicotinamide Riboside and Pterostilbene Protect Motor Neurons in ALS: Preclinical Findings

Synopsis Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that causes the gradual loss of motor neurons, largely due to oxidative stress and inflammation. In both human trials an...

A New Bioluminescent Probe to Monitor Mitochondrial Health Over Time: Preclinical Findings

SynopsisMitochondrial membrane potential (ΔΨm) is a key indicator of mitochondrial health and is involved in diseases like diabetes, cancer, Alzheimer’s, and Parkinson’s. This study introduces a ne...

In Ovo Nicotinamide Riboside Injection Improves Broiler Chicken Muscle Growth: Preclinical Findings

Synopsis This study examined how nicotinamide riboside (NR) affects the development and growth of the pectoralis major muscle (PM) in broiler chickens. Fertilized eggs were injected on day 10 of i...

Nicotinamide Riboside Helps Protect the Heart by Improving Mitochondrial Function: Preclinical Findings

Synopsis Endothelial-to-mesenchymal transition (EndMT) contributes to heart scarring (cardiac fibrosis), but how it happens and how to treat it is not fully known. Researchers found that a process...

Nicotinamide Riboside Protects Motor Neurons in ALS: Preclinical Findings

Synopsis Sirtuins (SIRTs) are enzymes that rely on NAD+ and help regulate DNA repair, metabolism, and oxidative stress. Boosting NAD+ levels can activate SIRTs and antioxidant proteins, reducing m...

Nicotinamide Riboside Regulates Inflammation and Improves Mitochondrial Function in Liver Cells: Preclinical Findings

Synopsis This study examined the effects of nicotinamide riboside (NR), a vitamin B3 derivative, on liver cells. Mouse hepatocytes were treated with palmitic acid to mimic fat-induced stress, then...