Mitochondria Can Directly Import NAD+ Through an Unknown Transporter: Preclinical Findings

Synopsis Mitochondrial NAD+ is essential for choosing energy sources, maintaining daily rhythms, and helping cells survive stress. Scientists have debated whether mitochondria make NAD+ from cytos...

Nicotinamide Riboside Protects Against DNA Damage in Cells By Increasing NAD+: Preclinical Findings

Synopsis Mitochondrial cytochrome c oxidase (COX, complex IV) helps cells make energy. When COX is deficient, it can cause neuromuscular problems and sometimes anemia. Researchers found that COX4-...

Effects of Nicotinamide Riboside on Mitochondrial Function in Rare Mitochondrial Disorder: Preclinical Findings

Synopsis Nicotinamide riboside (NR), a vitamin B3 derivative and precursor to NAD+, is known to support mitochondrial function and energy metabolism in many conditions. Researchers tested whether ...

CD38 Inhibitor Reverses Age-Related NAD+ Decline and Metabolic Dysfunction: Preclinical Findings

Synopsis Aging is characterized by the development of metabolic dysfunction and frailty. Recent studies show that a reduction in nicotinamide adenine dinucleotide (NAD+) is a key factor for the de...

Nicotinamide Riboside Protects Heart Function in Dilated Cardiomyopathy: Preclinical Findings

Synopsis In chronic heart failure, the heart’s energy metabolism is severely impaired. NAD+ is a key molecule that helps cells produce energy and respond to stress, making it an important focus in...

Nicotinamide Riboside Reduces Amyloid Plaque Formation and Improves Contextual Memory in Alzheimer's Disease: Preclinical Findings

Synopsis Alzheimer’s disease (AD) is a devastating neurodegenerative disorder driven by the accumulation of toxic amyloid-β (Aβ) protein aggregates. This study identifies a conserved mitochondrial...

Nicotinamide Riboside Restores Mitochondrial Function in Rev1-Deficient Cells: Preclinical Findings

Synopsis DNA, which carries the genetic information of all organisms, is constantly exposed to damage from both internal and external sources. If this damage—like single- or double-strand breaks—i...

Modulating NAD+ Metabolism from Preclinical to Clinical Application: Review

SynopsisFirst discovered in the early 1900s, nicotinamide adenine dinucleotide (NAD+) was once seen only as a helper in energy reactions but is now known to be essential for many regulatory protein...

Nicotinamide Riboside Reduces Inflammation and Supports Mitochondrial Health: Preclinical Findings

Synopsis Activation of the NLRP3 inflammasome, a key driver of inflammation linked to metabolic dysfunction, can be influenced by nutrient levels and mitochondrial health. In a study of healthy vo...

Nicotinamide Riboside Improves Mitochondrial Function in Mutant Human Cells: Preclinical Findings

Synopsis Mitochondrial disorders are severe genetic conditions that disrupt energy production, and currently, no effective treatments exist. This study explored whether boosting NAD+, a vital mole...

Nicotinamide Riboside Improved Endurance in Mitochondrial Disease: Preclinical Findings

Synopsis Mitochondrial disorders are rare but serious diseases caused by defects in the cell’s energy-producing machinery, known as the mitochondrial respiratory chain. These conditions often lead...

Nicotinamide Riboside Delays Mitochondrial Myopathy Disease Progression: Preclinical Findings

Synopsis Mitochondrial diseases disrupt the body’s ability to produce energy, leading to muscle weakness and other serious health problems. Because these disorders impair the balance of key energy...

Nicotinamide Riboside Enhances Mitochondrial Function and Extends Lifespan: Preclinical Findings

Synopsis NAD+ is a vital molecule that maintains metabolic balance and fuels sirtuin enzymes, which help regulate aging and energy use. In this study, researchers found that NAD+ levels decline wi...

Pathway for Mitochondrial NAD+ Production in Human Cells Revealed: Preclinical Findings

Synopsis NAD⁺ is an essential molecule for cellular energy and signaling, but how it is made and distributed inside human cells is not fully understood. In particular, the source of mitochondrial ...