Effects of Nicotinamide Riboside Supplementation on Nerve Fiber Protection and Axon Regeneration: Clinical Findings

Objectives To investigate whether boosting NAD+ levels through nicotinamide riboside (NR) supplementation can protect against or promote regeneration of small somatic sensory axons in human skin f...

Thiamine and Nicotinamide Riboside Improve Symptoms in Charcot-Marie-Tooth Neuropathy: Case Report

Objectives To identify the mechanistic basis of GDAP1 dysfunction in CMT2K and test whether targeted metabolic activation using thiamine and NR can therapeutically correct mitochondrial biochemica...

NR Restores Mitochondrial Function and Reduces Trigeminal Pain: Preclinical Findings

Synopsis In a mouse model of trigeminal neuropathic pain, the injured trigeminal ganglion (TG) showed profound mitochondrial dysfunction, affecting gene expression, protein synthesis, and respirat...

Low NMNAT2 Triggers SARM1 Activity and Alters Nicotinamide Riboside Response in Axons: Preclinical Findings

SynopsisNMNAT2 is a key protein that keeps axons healthy by blocking the pro-degenerative protein SARM1. Completely losing NMNAT2 in mice causes severe axon loss and early death, but removing SARM1...

Nicotinamide Riboside Prevents Chemotherapy-Induced Peripheral Neuropathy: Preclinical Findings

Synopsis Paclitaxel (PTX) is a widely used chemotherapy drug for cancers such as breast, lung, and ovarian cancer, but one of its major side effects is chemotherapy-induced peripheral neuropathy (...

Nicotinamide Riboside and Nicotinamide Mononucleotide Restore Nerve Function in Diabetic Neuropathy: Preclinical Findings

SynopsisReduced NAD+ signaling contributes to nerve degeneration in diabetic peripheral neuropathy. Researchers tested NAD+ precursors, nicotinamide riboside and nicotinamide mononucleotide, in cul...

Nicotinamide Riboside Improves Inflammation-Induced Chronic Pain | Preclinical Findings

Synopsis Many patients continue to feel pain even after inflammation has healed, but the reason has been unclear. This study found that mitochondrial dysfunction in sensory neurons—the nerve cells...

Nicotinamide Riboside Protects Gut Nerve Health and Improves Gastrointestinal Transit in Diabetes: Preclinical Findings

SynopsisDiabetes causes systemic oxidative stress that often leads to nerve damage in the enteric nervous system, impairing gut motility and causing symptoms such as constipation or diarrhea. Using...

Nicotinamide Riboside Reduces and Prevents Chemotherapy-Induced Peripheral Neuropathy: Preclinical Findings

SynopsisChemotherapy often causes peripheral neuropathy with no effective treatments. This study showed that NR, which activates the NAD-dependent enzyme SIRT2, prevents and reverses nerve damage c...

Nicotinamide Riboside Prevents Nerve Damage From Toxic Chemicals: Preclinical Findings

Synopsis Organophosphate-induced delayed neuropathy (OPIDN) is a serious condition caused by exposure to certain toxic chemicals, leading to nerve degeneration similar to Wallerian degeneration, w...

NAD+ Precursors Restore Mitochondrial Function and Prevent Nerve Damage in Diabetes: Preclinical Findings

SynopsisDiabetic peripheral neuropathy involves nerve degeneration linked to low NAD+ levels. Researchers tested whether NAD+ precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside ...

Nicotinamide Riboside Reduces Chemotherapy-Induced Eye and Body Hypersensitivity: Preclinical Findings

SynopsisChemotherapy often causes dry eye and nerve pain, which may be due to nerve damage. This study treated rats given the chemotherapy drug paclitaxel with nicotinamide riboside (NR). Paclitaxe...

Changes in NMN/NAD+ Ratio Activates SARM1 to Trigger Nerve Damage: Preclinical Findings

SynopsisAxon degeneration is a key feature of many neurodegenerative diseases. SARM1 is an enzyme that breaks down NAD+ and, when activated, causes axon destruction. The enzyme NMNAT2 normally conv...

The Effects of Nutraceutical and Drug Cocktails in Duchenne Muscular Dystrophy: Preclinical Findings

Synopsis Duchenne muscular dystrophy (DMD) causes muscle weakness leading to respiratory failure. Earlier, quercetin showed temporary respiratory benefits in a mouse model. This study tested querc...

Mild Vitamin B3 Deficiency Changes Gene Activity in White Fat Tissue: Preclinical Findings

Synopsis Mild vitamin B3 (niacin) deficiency is hard to detect. This study compared mice fed a diet without NR (vitamin B3 precursor) to those given recommended B3 levels, both with low tryptophan...

Nicotinamide Riboside Restores NAD+ Levels and Improves Heart Function in Cardiomyopathy: Preclinical Findings

Synopsis Cardiomyopathy caused by mutations in the lamin A/C gene (LMNA cardiomyopathy) leads to heart muscle and electrical dysfunction, often resulting in heart failure. Currently, there is no t...

Preventing NMN Accumulation Protects Nerves from Chemotherapy-Induced Damage: Preclinical Findings

Synopsis Axon degeneration is a key feature of chemotherapy-induced peripheral neuropathy (CIPN). While it has been linked to loss of NAD+ via SARM1, recent evidence suggests that a buildup of NMN...

NMNAT1 Protects Injured Axons by Preventing SARM1-Induced NAD+ Loss After Injury: Preclinical Findings

SynopsisOverexpression of the NAD+ biosynthesis enzyme NMNAT1 helps protect injured axons. Although it's believed that higher NAD+ levels or lower NMN levels are important for this protection, the ...

Nicotinamide Riboside Protects Against Diabetes and Neuropathy: Preclinical Findings

SynopsisMale C57BL/6J mice fed a high-fat diet (HFD) develop prediabetes with insulin resistance and sensory neuropathy. When given low doses of streptozotocin, these mice model type 2 diabetes (T2...