NAD+ Precursors Prevent Allergic Responses by Regulating Immune Function: Preclinical Findings

Synopsis Nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN)—both vitamin B3 derivatives that boost NAD+ levels—may help prevent severe allergic reactions such as anaphylaxis. In this...

Dihydronicotinamide Riboside Promotes a Pro-Inflammatory Macrophage Phenotype: Preclinical Findings

Synopsis This study explored how various NAD precursors—including nicotinamide riboside (NR), nicotinamide mononucleotide (NMN), nicotinamide (NAM), and a newer compound called NRH—influence the b...

Nicotinamide Riboside Supplementation Boosts NAD+ and Lowers Inflammatory Immune Signaling in Lupus: Clinical Findings

Objectives To explore the anti-inflammatory effects of NR in monocytes (a type of white blood cell; immune cell) extracted from young, healthy subjects following supplementation. Additionally, the...

Nicotinamide Riboside Suppresses Coronavirus Replication: Preclinical Findings

Synopsis Viruses like SARS-CoV-2, which causes COVID-19, rely on the host’s metabolism to reproduce. This study used a related coronavirus model in mice to explore how metabolic interventions coul...

Nicotinamide Riboside Improves Blood Cell Formation in Aging and Ataxia Telangiectasia: Preclinical Findings

SynopsisNAD+ supplements can boost mitochondrial health and DNA repair, which benefits stem cells in aging or disease. This study tested nicotinamide riboside (NR) in mice with reduced blood stem c...

Disrupted NAD+ Metabolism Leads to Brain Defects in Zika Virus-Linked Microcephaly: Preclinical Findings

Synopsis Zika virus (ZIKV) infection during pregnancy can cause microcephaly, a condition where babies are born with abnormally small brains. In this study, researchers analyzed infected mouse bra...

Unique Mutations in Mouse Hepatitis Virus Reduce Virus Replication: Preclinical Findings

SynopsisAll coronaviruses contain a small domain called the macrodomain, or Mac1, within the nonstructural protein 3 (nsp3). Mac1 binds to and removes a molecule called mono-ADP-ribose (MAR) that a...

Nicotinamide Riboside Supplementation Combined with Other Nutrients Accelerates Recovery in COVID-19 Patients: Clinical Findings

Objectives To investigate supplementation of the combined metabolic activators (CMA), consisting of L-serine, N-acetyl-L-cysteine (NAC), NR, and L-carnitine tartrate for the treatment of patients ...

Nicotinamide Riboside Reduces Alcohol-Induced Inflammation and Oxidative Stress in Immune Cells: Preclinical Findings

SynopsisMacrophages play an important role in inflammation and oxidative stress caused by alcohol. Researchers studied how nicotinamide riboside (NR), a precursor of NAD+, affects alcohol-induced i...

Counteracting CD38-Induced NAD+ Depletion Reduces Multiple Organ Fibrosis: Preclinical Findings

SynopsisSystemic sclerosis (SSc) involves fibrosis in multiple organs, but its cause is not fully understood. NAD+ decline with age and disease, often due to increased CD38 activity (an NADase), ma...

Nicotinamide Riboside Restores T-Cell Function in Tumors by Improving Mitochondrial Health: Preclinical Findings

Synopsis T cells that infiltrate tumors often become exhausted and lose their ability to fight cancer due to poor mitochondrial function and reduced mitophagy. This exhaustion involves lasting cha...

NAD+ Levels Control Inflammatory Responses in Immune Cells: Preclinical Findings

SynopsisNAD+ is important for cell metabolism and inflammation, but how it affects immune cells is not well understood. This study looked at how changing NAD+ levels using nicotinamide riboside (NR...

NAD-Related Compounds Affect Immune Cell Growth and Inflammatory Response: Preclinical Findings

Synopsis Nicotinamide (NAM), nicotinamide riboside (NR), and 1-methylnicotinamide (MNA) are compounds related to NAD+ that play important roles in cell signaling, including in the immune system. S...

Nicotinamide Riboside Protects Neurons More Effectively Than NAD+: Preclinical Findings

Synopsis Loss of NAD+ is common in neurodegenerative diseases. Excitotoxicity, caused by excessive stimulation of neurons, leads to nerve damage. This study found that nicotinamide riboside (NR), ...

NAD+ Biosynthesis Enzyme Protects Aortic Smooth Muscle Cells: Preclinical Findings

Synopsis The walls of the aorta weaken with age and stress, risking serious damage. Smooth muscle cells (SMCs) in the aorta need NAD+, made by the enzyme NAMPT, for health. In humans with aortic d...

Exploring NAD+ Metabolism in Host–Pathogen Interactions: Review

SynopsisNAD+ is found in all living cells and is controlled by its production, recycling, and breakdown. It is already a drug target for diseases like cancer, neurodegeneration, and inflammation, a...

How NAD+ Recycling Pathways Influence Virulence in Pneumonia Bacteria: Preclinical Findings

SynopsisNAD is an essential molecule found in all living cells. Some bacteria, like Streptococcus pneumoniae, cannot make NAD from scratch and must recycle it by importing related compounds such as...