Article: Nicotinamide Riboside Protects Neurons More Effectively Than NAD+: Preclinical Findings

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Immune Health Metabolic Health Preclinical

Nicotinamide Riboside Protects Neurons More Effectively Than NAD+: Preclinical Findings

Synopsis

Loss of NAD+ is common in neurodegenerative diseases. Excitotoxicity, caused by excessive stimulation of neurons, leads to nerve damage. This study found that nicotinamide riboside (NR), a NAD+ precursor, protects brain neurons better than NAD+ itself against excitotoxic damage caused by NMDA. NR’s protective effects depend on the neuron’s internal NAD+ balance and uptake of NR. This suggests NR is a promising agent for preventing nerve damage in excitotoxic conditions.

Journal

The FASEB Journal

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