Article: Nicotinamide Riboside Supplementation Supports Immune Regulation in Human Cells and Blood: Clinical Findings

Mar 5, 2024 Clinical Immune Health

Nicotinamide Riboside Supplementation Supports Immune Regulation in Human Cells and Blood: Clinical Findings

Objectives

To investigate how NR influences the migration of macrophages and the underlying mechanisms behind this effect.

Journal

Cells

Key Outcomes

Ex Vivo:

NR treatment increased levels of NAD+ and prostaglandin E2 (PGE2), a key regulator of inflammatory and immune responses, in monocytes from healthy subjects.

In Vivo:

NR supplementation increased PGE2 levels in human serum.

Duration

1 week

Dose

1000 mg

Study Design

Ex Vivo:
Monocytes were extracted from young, healthy subjects and then treated with NR

In Vivo:
Randomized, double-blind, placebo-controlled, pilot study in 36 young, healthy subjects

See Published Study

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The Impact of Nicotinamide Adenine Dinucleotide Deficiency on Mammalian Development: Review

SynopsisNAD+ is a molecule made from tryptophan or vitamin B3 that's essential for many cell processes. During pregnancy, NAD+ deficiency can cause congenital NAD+ deficiency disorder (CNDD), which...