Equilibrative Nucleoside Transporters Transport Nicotinamide Riboside and Nicotinic Acid Riboside into Human Cells: Preclinical Findings

Synopsis Nicotinamide riboside (NR), a form of vitamin B3, is known to boost levels of NAD+, a vital molecule for energy production and cellular repair. However, how NR gets into cells has remaine...

Nicotinamide Riboside Protects Lens Cells from Oxidative Stress: Preclinical Findings

Synopsis Researchers found that nicotinamide riboside (NR), a vitamin B3 derivative and NAD+ precursor, can protect eye lens cells from oxidative stress, one of the main causes of cataracts. In la...

Tracking NAD+ Metabolism in Real Time Using a Genetically Encoded Fluorescent Sensor: Preclinical Findings

Synopsis Tracking NAD+ metabolism in living cells and animals is challenging, but FiNad sensors make it possible. These fluorescent, genetically encoded sensors can detect changes in NAD+ levels i...

Nicotinamide Riboside Increases Platelet NAD+ but Does Not Extend Their Lifespan: Preclinical Findings

Synopsis Nicotinamide riboside (NR), a vitamin B3 derivative and precursor to NAD+, has been shown in many studies to extend the lifespan of cells and tissues by improving energy metabolism and ce...

Electrochemical Behavior of Nicotinamide Riboside Reveals Its Activity in Biological Systems: Preclinical Findings

Synopsis Nicotinamide riboside (NR) is a popular supplement that boosts NAD+, a molecule important for energy metabolism and functions like vision, hearing, and cognition. NAD+ naturally declines ...

Measurement of NAD+ Precursors, Including Nicotinamide Riboside, in Human Milk: Preclinical Findings

Synopsis B-vitamins are essential for infant growth and metabolism, and vitamin B3 (niacin)—including nicotinamide (NM) and nicotinic acid (NA)—serves as a precursor for the coenzyme NAD+, which i...

Preventing NMN Accumulation Protects Nerves from Chemotherapy-Induced Damage: Preclinical Findings

Synopsis Axon degeneration is a key feature of chemotherapy-induced peripheral neuropathy (CIPN). While it has been linked to loss of NAD+ via SARM1, recent evidence suggests that a buildup of NMN...

Effects of Nicotinamide Riboside on Energy Metabolism and Exercise Performance: Preclinical Findings

Synopsis Nicotinamide riboside (NR) is a form of vitamin B3 that can boost NAD(P) levels, which are important for energy metabolism in cells. While previous studies in older or sick mice showed th...

Mitochondria Can Directly Import NAD+ Through an Unknown Transporter: Preclinical Findings

Synopsis Mitochondrial NAD+ is essential for choosing energy sources, maintaining daily rhythms, and helping cells survive stress. Scientists have debated whether mitochondria make NAD+ from cytos...

Nicotinamide Riboside Protects Against DNA Damage in Cells By Increasing NAD+: Preclinical Findings

Synopsis Mitochondrial cytochrome c oxidase (COX, complex IV) helps cells make energy. When COX is deficient, it can cause neuromuscular problems and sometimes anemia. Researchers found that COX4-...

Nicotinamide Riboside Protects Organs and Improves Survival in Sepsis: Preclinical Findings

Synopsis Sepsis, a life-threatening condition caused by the body’s extreme response to infection, often leads to multiple organ failure and remains one of the top causes of death in intensive care...

Effects of Nicotinamide Riboside on Mitochondrial Function in Rare Mitochondrial Disorder: Preclinical Findings

Synopsis Nicotinamide riboside (NR), a vitamin B3 derivative and precursor to NAD+, is known to support mitochondrial function and energy metabolism in many conditions. Researchers tested whether ...

Nicotinamide Riboside Converts into NAD+ without Breaking Down into Nicotinamide: Preclinical Findings

Synopsis NAD+ is a key molecule used in many cellular processes, not just energy production, but also in regulating important enzymes. Understanding how cells make NAD+ is therefore very important...

Tracking NAD+ Production and Breakdown Pathways: Preclinical Findings

Synopsis NAD+ (nicotinamide adenine dinucleotide) is a key molecule for metabolism and is used by important signaling enzymes like PARPs and sirtuins. NAD+ levels decline with age, so scientists a...

Therapeutic Potential of NAD-Boosting Molecules: Review

SynopsisNicotinamide adenine dinucleotide (NAD+) is best known as a hydrogen carrier in energy-producing reactions, but it also acts as a signaling molecule that controls hundreds of vital processe...

Age-Related Changes in NAD Metabolome and Nicotinamide Riboside Levels: Preclinical Findings

Synopsis Nicotinamide adenine dinucleotide (NAD+) is an important molecule that helps cells produce energy and control gene activity. NAD+ levels naturally decline with age, and giving animals NAD...

The Biology and Therapeutic Potential of Nicotinamide Riboside and Nicotinamide Mononucleotide: Review

SynopsisResearch on NAD+ biology has surged, especially around two intermediates—nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN)—which show promise in preventing and treating age-r...

Nicotinamide Riboside Restores Mitochondrial Function in Rev1-Deficient Cells: Preclinical Findings

Synopsis DNA, which carries the genetic information of all organisms, is constantly exposed to damage from both internal and external sources. If this damage—like single- or double-strand breaks—i...

NAD+ in Aging: Molecular Mechanisms and Translational Implications: Review

SynopsisNAD+ is vital for energy production and helping cells adapt to stress, especially in high-energy tissues like the brain. NAD+ levels drop with age, contributing to chronic diseases such as ...

Modulating NAD+ Metabolism from Preclinical to Clinical Application: Review

SynopsisFirst discovered in the early 1900s, nicotinamide adenine dinucleotide (NAD+) was once seen only as a helper in energy reactions but is now known to be essential for many regulatory protein...