Therapeutic Potential of NAD-Boosting Molecules: Review

Synopsis

Nicotinamide adenine dinucleotide (NAD+) is best known as a hydrogen carrier in energy-producing reactions, but it also acts as a signaling molecule that controls hundreds of vital processes, from metabolism to cell survival, by regulating NAD-sensitive enzymes. Its levels fluctuate with diet, exercise, and daily rhythms but steadily drop with age, leading to poorer metabolism and higher disease risk. Restoring NAD+ in aged or diseased animals has improved health and lifespan, sparking interest in safe NAD-boosting compounds that could increase resistance to many diseases and extend healthy human life.

JOURNAL

Cell Metabolism