Article: NAD+ in Aging: Molecular Mechanisms and Translational Implications: Review

PrevNext
Healthy Aging & Longevity Review.Cellular Health

NAD+ in Aging: Molecular Mechanisms and Translational Implications: Review

Synopsis

NAD+ is vital for energy production and helping cells adapt to stress, especially in high-energy tissues like the brain. NAD+ levels drop with age, contributing to chronic diseases such as Alzheimer's, Parkinson's, heart disease, and muscle loss. Evidence shows NAD+ depletion happens in many tissues as we age, and boosting NAD+—through lifestyle or medical interventions—might slow aging and prevent some age-related diseases. This review looks at how NAD+ is made, how it helps counteract aging, and what preclinical and clinical trials have found so far.

JOURNAL

Trends in Molecular Medicine

Share

Read more

Cellular Health

Modulating NAD+ Metabolism from Preclinical to Clinical Application: Review

SynopsisFirst discovered in the early 1900s, nicotinamide adenine dinucleotide (NAD+) was once seen only as a helper in energy reactions but is now known to be essential for many regulatory protein...

Read more
Cellular Health

The Biology and Therapeutic Potential of Nicotinamide Riboside and Nicotinamide Mononucleotide: Review

SynopsisResearch on NAD+ biology has surged, especially around two intermediates—nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN)—which show promise in preventing and treating age-r...

Read more