Using Engineered Cancer Cells to Identify How Orphan Cytotoxins Work: Preclinical Findings

Synopsis Orphan cytotoxins are small molecules whose exact targets or mechanisms are unknown. Understanding how they work can reveal new research tools and potential therapies. To help identify th...

Restoring NAD+ with Nicotinamide Riboside Improves Metabolism and Autophagy in DNA Repair Deficiency: Preclinical Findings

SynopsisLoss of Rev1, a DNA repair protein, causes replication stress, mitochondrial dysfunction, and metabolic imbalance. This study found that mouse embryonic fibroblasts lacking Rev1 had altered...

Nicotinamide Riboside Enhances SIRT5 Activity to Support Mitochondrial Function: Preclinical Findings

Synopsis Sirtuins are a family of enzymes that depend on NAD+ to regulate key cellular processes such as DNA repair, metabolism, and aging. Among them, SIRT5 plays an important role in protecting ...

Impact of Nicotinamide Riboside on DNA Repair: Preclinical Findings

Synopsis Nicotinamide adenine dinucleotide (NAD+) is vital for enzymes like sirtuins and PARPs, which help cells repair DNA double-strand breaks (DSBs)—a severe type of genetic damage caused by ra...

Nicotinamide Riboside Restores NAD+ and Improves Survival of Neurons with Autophagy Defects: Preclinical Findings

SynopsisAutophagy is a cellular recycling process vital for neuron survival, and its failure contributes to neurodegenerative diseases. This study generated human neurons lacking the autophagy gene...

Effects of Nicotinamide Riboside in Hyperammonemia: Preclinical Findings

Synopsis Excess ammonia in the body disrupts metabolism and contributes to cellular aging (senescence) by damaging mitochondria and disturbing the NAD+/NADH redox balance, which is vital for energ...

Metabolic Engineering of E. coli Enables Efficient Biosynthesis of Nicotinamide Riboside: Preclinical Findings

Synopsis Researchers developed a highly efficient biotechnological method to produce nicotinamide riboside (NR)—a vital precursor of NAD+—using engineered E. coli bacteria. They identified that th...

Host Nicotinamide Feeds Gut Microbiome to Support NAD+ Metabolism: Preclinical Findings

Synopsis Researchers found that gut bacteria play an important role in how the body produces NAD+, a molecule that helps cells create energy and stay healthy. When we eat vitamin B3 forms like nic...

Mitochondrial PARP1 Regulates Mitochondrial DNA and Aging: Preclinical Findings

Synopsis Scientists have discovered that the enzyme PARP1, known for repairing DNA in the cell nucleus, is also active inside mitochondria, where it helps control mitochondrial DNA (mtDNA). Using ...

Autophagy Promotes Cell Survival by Maintaining Stable NAD+ Levels: Preclinical Findings

SynopsisAutophagy is a cellular process that removes damaged parts of the cell and is important for healthy aging. When autophagy is lost, NAD+ levels fall due to increased activity of enzymes that...

Tracking Nicotinamide Riboside Uptake in Cancer Cells: Preclinical Findings

Synopsis Researchers developed a bioluminescent probe (BiNR) to visualize how nicotinamide riboside (NR)—a vitamin B3–derived NAD+ booster—is taken up by cells and tissues in real time. This tool ...

Blocking PNP Increases Nicotinamide Riboside Effectiveness for NAD+: Preclinical Findings

Synopsis Nicotinamide riboside (NR), a vitamin B3 derivative and precursor to nicotinamide adenine dinucleotide (NAD+), helps boost cellular energy and repair mechanisms. While NR supplementation ...

NAD+ Precursors: A Questionable Redundancy: Review

SynopsisIn the last decade, there's been growing interest in treating metabolic and age-related diseases by boosting NAD+ levels in cells. The most common approach is taking NAD+ precursors, a grou...

Nicotinamide Riboside Supports Long-Term Function of Blood Stem Cells: Preclinical Findings

Synopsis Hematopoietic stem cells (HSCs), which produce blood cells, adjust their metabolism depending on whether they are resting or dividing. When HSCs are in maintenance mode, they break down a...

Nicotinamide Riboside and Natural Antioxidants Protect Against Radiation Damage and Improve Survival: Preclinical Findings

Synopsis Researchers tested whether natural compounds could protect against harmful ionizing radiation, which has applications in medicine, space travel, and biotechnology. In mice exposed to leth...

Nicotinamide Riboside Protects Cells From Oxidative Damage: Preclinical Findings

Synopsis Oxidative stress, caused by an overload of reactive oxygen species, can make cells die either by apoptosis (a controlled process) or necrosis (an uncontrolled one). Scientists found that ...

Selective Mitochondrial Inheritance Links Metabolism to Cell Fate: Preclinical Findings

Synopsis This study discovered that the age of mitochondria—the cell’s energy-producing structures—plays a major role in determining how stem cells divide and develop. In epithelial stem-like cell...

Nicotinamide Riboside Suppresses Coronavirus Replication: Preclinical Findings

Synopsis Viruses like SARS-CoV-2, which causes COVID-19, rely on the host’s metabolism to reproduce. This study used a related coronavirus model in mice to explore how metabolic interventions coul...

Nicotinamide Riboside Increases NAD+ Through Two Distinct Pathways: Preclinical Findings

Synopsis Nicotinamide riboside (NR), a precursor to NAD+, can increase NAD+ levels in the body through two mechanisms. When taken orally, NR is first directly absorbed and converted to NAD+ via th...

Yeast-Mediated Nicotinamide Riboside Production in Craft Beers: Preclinical Findings

Synopsis Researchers measured nicotinamide riboside (NR), NAD+, and NMN levels in commercial and lab-scale beers. All beers contained NAD+, but NR and NMN were only found in beers made with certai...