Article: Modulating NAD+ Metabolism from Preclinical to Clinical Application: Review

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Cellular Health Mitochondrial Health Review

Modulating NAD+ Metabolism from Preclinical to Clinical Application: Review

Synopsis

First discovered in the early 1900s, nicotinamide adenine dinucleotide (NAD+) was once seen only as a helper in energy reactions but is now known to be essential for many regulatory proteins, including sirtuins, which influence metabolism and longevity. Problems with NAD+ metabolism are linked to aging and diseases affecting metabolism, muscles, and the nervous system, while raising NAD+ levels has shown benefits in many conditions. This review covers the basics of NAD+ biology and how boosting it can help maintain healthy mitochondria, improve health, and potentially extend lifespan.

JOURNAL

The EMBO Journal

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