Article: Modulating NAD+ Metabolism from Preclinical to Clinical Application: Review

PrevNext
Cellular Health Mitochondrial Health Review

Modulating NAD+ Metabolism from Preclinical to Clinical Application: Review

Synopsis

First discovered in the early 1900s, nicotinamide adenine dinucleotide (NAD+) was once seen only as a helper in energy reactions but is now known to be essential for many regulatory proteins, including sirtuins, which influence metabolism and longevity. Problems with NAD+ metabolism are linked to aging and diseases affecting metabolism, muscles, and the nervous system, while raising NAD+ levels has shown benefits in many conditions. This review covers the basics of NAD+ biology and how boosting it can help maintain healthy mitochondria, improve health, and potentially extend lifespan.

JOURNAL

The EMBO Journal

Share

Read more

Clinical

Nicotinamide Riboside Supplementation Is Orally Bioavailable in Both Mice and Humans: Clinical Findings

Objectives To determine the time and dose-dependent effects of NR supplementation on blood NAD+ metabolism in humans. Journal Nature Communications Key Outcomes Single oral doses of NR significan...

Read more
Healthy Aging & Longevity

NAD+ in Aging: Molecular Mechanisms and Translational Implications: Review

SynopsisNAD+ is vital for energy production and helping cells adapt to stress, especially in high-energy tissues like the brain. NAD+ levels drop with age, contributing to chronic diseases such as ...

Read more