Interaction Between Renalase and Molecules to Regulate Cellular Energy: Preclinical Findings

Synopsis Renalase is an enzyme that helps convert unusual forms of NADH and NADPH—called 2- and 6-isomers—back into their normal active forms, NAD+ and NADP+. These unusual forms can block other i...

Quantification of Nicotinamide Riboside, Nicotinamide Mononucleotide, and NAD+ in Human and Donkey Milk: Preclinical Findings

Synopsis Nicotinamide riboside (NR)—the newest identified form of vitamin B3—and its phosphorylated derivative nicotinamide mononucleotide (NMN) are powerful precursors that increase intracellular...

Inhibition of NAMPT and CD73 Suppresses Tumor Growth: Preclinical Findings

Synopsis Researchers are exploring new ways to treat ovarian cancer by targeting how tumor cells produce and recycle energy. This study focused on NAD+, a key molecule for cellular metabolism, and...

Nicotinamide Riboside and Nicotinic Acid Riboside Production in Human Cells: Preclnical Findings

Synopsis Nicotinamide adenine dinucleotide (NAD+) is essential for energy metabolism and many cell signaling processes, but because it is constantly used and broken down, cells must continuously r...

Human CD157 Enzyme Regulates NAD+ Precursors to Support Metabolism: Preclinical Findings

Synopsis Human CD157 (hCD157) is an enzyme that helps regulate cell metabolism and immune function and may be linked to neurodegenerative and metabolic diseases. Researchers found that hCD157 brea...

Nicotinamide Riboside Transporter Mediates AICAr Uptake in Yeast, But Not Human Cells: Preclinical Findings

Synopsis This study focuses on cellular metabolism and examines how cells take up and respond to a compound called AICAR, which mimics a low-energy state and can slow cell growth. AICAR must enter...

Newly Discovered NADase Enzyme and Nicotinamide Riboside Regulate NAD+ Levels and Red Blood Cell Production: Preclinical Findings

Synopsis NADases are enzymes that break down NAD+ into smaller molecules, but their exact role isn't clear. This study found a new NADase on the surface of rabbit red blood cell precursors. It is ...

NR and NMN Influence NAD+ Metabolism to Improve Anti-Cancer Therapy: Preclinical Findings

Synopsis In human cells, NAD+ is mainly produced through “salvage” pathways that recycle precursors like nicotinamide, nicotinic acid, and nicotinamide riboside (NR). Blocking this process with th...

Nicotinamide Riboside Protects Against High-Fat Diet-Induced Obesity: Preclinical Findings

Synopsis NAD+ is a crucial molecule required for the activity of sirtuin enzymes, which regulate energy use and cellular health. Because of this, adjusting NAD+ levels has become an important way ...

Yeast Control NAD+ Levels by Regulating Nicotinamide Riboside and Nicotinic Acid Export: Preclinical Findings

Synopsis NAD+ serves as both a key coenzyme in metabolic reactions and a substrate for enzymes like sirtuins that regulate aging and stress responses. Its synthesis is essential for extending life...

Pathway for Mitochondrial NAD+ Production in Human Cells Revealed: Preclinical Findings

Synopsis NAD⁺ is an essential molecule for cellular energy and signaling, but how it is made and distributed inside human cells is not fully understood. In particular, the source of mitochondrial ...

Nicotinamide Riboside and Nicotinic Acid Riboside Metabolism in Fungi and Mammals: Preclinical Findings

Synopsis NAD+ is an important coenzyme that helps many cellular reactions and supports enzymes like sirtuins, which regulate aging and stress responses. In yeast, adding nicotinamide riboside (NR)...

Gene Identified That Encodes Nicotinamide Riboside Transporter: Preclinical Findings

Synopsis Nicotinamide riboside is a newly identified precursor of NAD+, a vital coenzyme involved in energy metabolism and sirtuin activity. Supplementing yeast with nicotinamide riboside extends ...

Structural Insights Into Nicotinamide Riboside Kinase Reveal How Cells Make NAD+: Preclinical Findings

Synopsis The nicotinamide riboside kinase (Nrk) pathway, active in eukaryotic cells, plays a vital role in converting nicotinamide riboside into nicotinamide adenine dinucleotide (NAD⁺), an essent...

NAD+ Metabolism in Health and Disease: Review

SynopsisNicotinamide adenine dinucleotide (NAD+) is a molecule that helps enzymes in energy reactions and is also used by other enzymes involved in DNA repair, cell signaling, and regulating cell h...

Discovery of Nicotinamide Riboside as a Natural NAD+ Precursor in Humans and Yeast: Preclinical Findings

Synopsis Nicotinamide adenine dinucleotide (NAD+) is a vital molecule required by all living organisms. It functions both as a coenzyme that supports energy-producing reactions and as a source of ...