Nicotinamide Riboside Restores Mitochondrial Balance and Protects the Diabetic Heart: Preclinical Findings

Synopsis In diabetes, heart damage often occurs because of mitochondrial imbalance, where the cell’s energy-producing structures become fragmented and dysfunctional. This study found that nicotina...

Increasing NAD+ with NR Protects Against Aortic Aneurysms: Preclinical Findings

Synopsis Researchers found that weakened mitochondrial function in blood vessel walls contributes to aortic aneurysms and ruptures, which can cause sudden death. In mice prone to atherosclerosis a...

Nicotinamide Riboside Restores Heart Energy and Function in Heart Failure: Preclinical Findings

Synopsis More than half of people with heart failure have a condition called heart failure with preserved ejection fraction (HFpEF), but its causes are not well understood and current treatments a...

Nicotinamide Riboside Protects Against Cardiac Hypertrophy by Reducing Inflammation and Oxidative Stress: Preclinical Findings

Synopsis Cardiac hypertrophy, a thickening of the heart muscle caused by pressure overload, can lead to heart failure. In mice, nicotinamide riboside (NR), a precursor to NAD+, reduced heart and l...

NAD+ Precursors in Health, Disease, and Aging: Review

SynopsisNAD+ is an essential molecule that helps the body make energy, send signals between cells, keep mitochondria healthy, and decide whether cells survive or die. Research shows that NAD+ level...

Nicotinamide Riboside Reduces Heart Damage in Presence of Fentanyl, Midazolam, and Cangrelor: Preclinical Findings

SynopsisWhen blood flow to the heart is blocked and then restored—a process called ischemia-reperfusion injury—cells can be severely damaged. Researchers tested several potential protective compoun...

Unstable NAD+ Metabolism Leads to Impaired Heart Mitochondrial Function: Preclinical Findings

SynopsisPoly(ADP-ribose) polymerase (PARP) enzymes repair DNA but use NAD+ as fuel. Excessive DNA damage in heart cell mitochondria can overactivate PARP, depleting NAD+ and impairing mitochondrial...

Nicotinamide Riboside Improves Wound Healing in Diabetes: Preclinical Findings

Synopsis Poor wound healing is a common complication of diabetes, largely due to impaired blood vessel formation. This study found that nicotinamide riboside (NR), a vitamin B3 derivative and NAD+...

Nicotinamide Riboside Restores Mitochondrial Function and Improves Heart Failure with Preserved Ejection Fraction: Preclinical Findings

SynopsisHeart Failure with Preserved Ejection Fraction (HFpEF) is a serious heart condition without effective treatments. In a mouse model of HFpEF, researchers found impaired mitochondrial fatty a...

Nanocrystal Nicotinamide Riboside Improves Absorption and Protects the Heart: Preclinical Findings

Synopsis Nicotinamide riboside (NR), a vitamin B3 derivative that boosts NAD+ to support mitochondrial energy, often loses effectiveness when taken orally because it breaks down too quickly in the...

Nicotinamide Riboside Lowers Cardiometabolic Risk Factors and Cardiac Oxidative Stress: Preclinical Findings

Synopsis Nicotinamide riboside (NR), known to boost NAD levels, was tested alone and combined with calorie restriction (CR) to evaluate effects on obesity and heart health in rats fed a high-calor...

Nicotinamide Riboside Supplementation Reduces Inflammation in Heart Failure Patients: Clinical Findings

Objectives To investigate the mechanistic link between mitochondrial dysfunction and inflammatory activation in peripheral blood mononuclear cells (PBMCs), and the potential anti-inflammatory effe...

Nicotinamide Riboside Protects Against Obesity-Induced Atrial Fibrillation: Preclinical FIndings

Synopsis Aging and obesity increase the risk of atrial fibrillation (AF), a condition where the heart beats irregularly. Nicotinamide phosphoribosyltransferase (Nampt) produces NAD+, which is cruc...

Nicotinamide Riboside Improves Social Behavior and Anxiety in Autism: Preclinical Findings

Synopsis Oxytocin (OT) is essential for social recognition, memory, and emotional behaviors, and it also reduces anxiety, especially during stress. CD38 is an enzyme that produces cyclic ADP-ribos...

Nicotinamide Riboside Reverses Age-Related Circadian and Mitochondrial Decline: Preclinical Findings

Synopsis Aging disrupts sleep patterns and circadian rhythms, which are linked to metabolic diseases and lower NAD+ levels. This study shows that supplementing with the NAD+ precursor nicotinamide...

Nicotinamide Riboside Improves DNA Repair, Inflammation, and Atherosclerosis: Preclinical Findings

Synopsis Atherosclerosis, the buildup of fatty plaques in arteries, is a leading cause of heart disease. Beyond cholesterol and inflammation, new research shows that DNA damage in blood vessels al...

Nicotinamide Riboside Protects the Brain from Hypertension-Related Small Vessel Damage: Preclinical Findings

Synopsis Hypertension can cause damage to small blood vessels in the brain, leading to memory problems and white matter injury, but treatments are limited. In this study, mice with angiotensin-ind...

Nicotinamide Riboside Prevents Hearing Loss in Cockayne Syndrome: Preclinical Findings

Synopsis Age-related hearing loss (ARHL) is one of the most common disorders affecting elderly individuals. There is an urgent need for effective preventive measures for ARHL because none are curr...

Nicotinamide Riboside Helps Protect the Heart by Improving Mitochondrial Function: Preclinical Findings

Synopsis Endothelial-to-mesenchymal transition (EndMT) contributes to heart scarring (cardiac fibrosis), but how it happens and how to treat it is not fully known. Researchers found that a process...

Nicotinamide Riboside Protects the Heart from the Cardiotoxic Effects of Doxorubicin, a Chemotherapy Drug: Preclinical Findings

Synopsis Doxorubicin (DOX) is a common chemotherapy drug, but it can seriously damage the heart, partly due to oxidative stress. Normally, heart cells use autophagy to remove damaged components an...