Article: Nicotinamide Riboside Protects Against Cardiac Hypertrophy by Reducing Inflammation and Oxidative Stress: Preclinical Findings

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Cardiovascular Disease Cardiovascular Health Preclinical

Nicotinamide Riboside Protects Against Cardiac Hypertrophy by Reducing Inflammation and Oxidative Stress: Preclinical Findings

Synopsis

Cardiac hypertrophy, a thickening of the heart muscle caused by pressure overload, can lead to heart failure. In mice, nicotinamide riboside (NR), a precursor to NAD+, reduced heart and lung enlargement, improved heart function, and lowered levels of stress markers caused by transverse aortic constriction. NR boosted NAD+ and Sirtuin3 activity in the heart, reduced oxidative stress, and dampened inflammation by inhibiting NLRP3 inflammasome activation. Overall, NR protected the heart from structural and functional damage by improving mitochondrial health and controlling inflammatory signaling.

Journal

Oxidative Medicine and Cellular Longevity

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