Nicotinamide Riboside and B Vitamins Restore Heart Energy in Heart Failure: Preclinical Findings

Synopsis Heart failure (HF) affects the heart’s energy supply, but current treatments do not directly fix this problem. In a study using mice with established HF, a diet supplemented with three B ...

Nicotinamide Riboside Prevents Diabetic Cardiomyopathy: Preclinical Findings

Synopsis In a mouse model of diabetic cardiomyopathy (DCM) induced by STZ and a high-fat diet, nicotinamide riboside (NR) (400 mg/kg/day) lowered fasting glucose and insulin levels, improved diast...

NR Restores NAD+ and Protects Heart Cells from Fatty Acid Damage: Preclinical Findings

Synopsis This study looks at how fatty acids (FAs) affect heart cells (cardiomyocytes) by reducing their ability to take in glucose, especially after a lack of oxygen (ischemia–reperfusion injury)...

Nicotinamide Riboside Supplementation Combined with Exercise May Improve Nighttime Blood Pressure and Arterial Stiffness: Clinical Findings

Objectives To evaluate whether combining aerobic exercise with NR could enhance blood pressure (BP) control in sedentary older adults with hypertension. Journal GeroScience Key Outcomes NR+Ex was...

Nicotinamide Riboside Restores Vascular Health in ACTA2 Mutation: Preclinical Findings

Synopsis Mutations in ACTA2 affecting arginine 179 cause early-onset strokes due to moyamoya-like artery blockages. This study found that mutant smooth muscle cells (SMCs) remain immature, highly ...

Nicotinamide Riboside Restores Mitochondrial Function in Aortic Aneurysms: Preclinical Findings

Synopsis Thoracic aortic aneurysms (TAA) are deadly vascular disorders linked to genetic mutations such as ACTA2R179H and TGFBR2G357W, which disrupt vascular smooth muscle cell (VSMC) function. Th...

Nicotinamide Riboside Improves Vascular and Cognitive Health in Peripheral Artery Disease: Clinical Findings

Objectives To investigate the potential for NR to counteract the age-related vascular and cognitive decline in peripheral artery disease (PAD) patients. Journal The Journal of Pharmacology and Exp...

Nicotinamide Riboside Protects Against Doxorubicin Cardiotoxicity: Preclinical Findings

Synopsis In human iPSC-derived cardiomyocytes, nicotinamide riboside (NR) improved mitochondrial fusion, enhanced oxidative phosphorylation and ATP production, and upregulated ERRα, a key metaboli...

Nicotinamide Riboside Restores Lipid Handling in Diabetic Heart Disease: Preclinical Findings

Synopsis Excessive lipid droplet buildup and lipotoxicity contribute to diabetic cardiomyopathy (DCM). This study found that lipophagy—the autophagic breakdown of lipid droplets—is impaired in DCM...

The Effects of Boosting NAD+ on Atherosclerosis and Inflammation: Preclinical Findings

SynopsisNAD+ is a key molecule that activates sirtuins, which are linked to benefits like lifespan extension and improved metabolism in mice. Supplements like nicotinamide riboside (NR) are used to...

Nicotinamide Riboside Protects Kidneys after Heart Attack: Preclinical Findings

SynopsisCardiorenal syndrome type 1 occurs when acute kidney injury (AKI) develops after sudden heart problems like a heart attack (MI), increasing the risk of death. This study tested whether nico...

NMN and NR Improve Lipid Metabolism but Promote Atherosclerosis in ApoE-Knockout Mice: Preclinical Findings

Synopsis Supplementation with nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) raised NAD+ levels and produced clear metabolic benefits in mice, including reduced body weight, lowe...

Mitochondrial Activators Like Nicotinamide Riboside Help Heart Cell Function: Preclinical Findings

SynopsisMitochondrial dysfunction in failing hearts can cause energy shortages in heart cells. This study tested how isoproterenol (ISO), a compound that stresses heart cells, affects mitochondria ...

NAD+ Depletion Is Central to Placental Dysfunction in an Inflammatory Subclass of Preeclampsia: Preclinical Findings

Synopsis Preeclampsia (PE) is a dangerous pregnancy complication marked by high blood pressure, inflammation, and placental dysfunction, leading to serious risks for both mother and baby. This stu...

Nicotinamide Riboside Prevents Cardiac Death: Preclinical Findings

Synopsis This study revealed that maintaining NAD+ levels is critical for heart health and rhythm stability. Researchers found that when Nampt, the key enzyme responsible for NAD+ production, was ...

Nicotinamide Riboside Protects the Heart from Blood Flow Injury: Preclinical Findings

SynopsisMyocardial ischemia-reperfusion (I/R) injury damages the heart when blood flow returns to previously blocked tissue, causing oxidative stress, inflammation, and cell death. This study teste...

NAD+ Metabolism and Heart Failure: Review

SynopsisNAD+, along with its reduced form NADH, is central to energy metabolism and is also the starting point for NADP+ production and a co-substrate for key enzymes that regulate oxidative stress...

Nicotinamide Riboside Extends Lifespan and Restores Cardiac Function in Friedreich’s Ataxia: Preclinical Findings

Synopsis Friedreich’s ataxia (FRDA) is a rare inherited disease caused by reduced production of frataxin, a mitochondrial protein essential for iron-sulfur cluster formation. The condition leads t...

Nicotinamide Riboside Protects Against Brain Injury in Intracerebral Hemorrhage: Preclinical Findings

Synopsis Hemorrhagic stroke, caused by bleeding within the brain, is a severe condition with high disability and death rates. This study examined whether nicotinamide riboside (NR)—a vitamin B3–de...

Nicotinamide Riboside Supplementation Enhances Walking Performance in Peripheral Artery Disease: Clinical Findings

Objectives To assess the effects of NR supplementation alone and in combination with resveratrol on the six-minute walk distance in individuals with peripheral artery disease (PAD). Journal Natur...