Nicotinamide Riboside Supplementation Enhances Walking Performance in Peripheral Artery Disease: Clinical Findings

Objectives To assess the effects of NR supplementation alone and in combination with resveratrol on the six-minute walk distance in individuals with peripheral artery disease (PAD). Journal Natur...

Nicotinamide Riboside Supplementation Is Safe and Well-Tolerated in Heart Failure Patients: Clinical Findings

Objectives To assess the safety and tolerability of NR in patients with Stage C heart failure with reduced ejection fraction (HFrEF). Journal JACC: Basic to Translational Science Key Outcomes Hig...

Nicotinamide Riboside Supplementation Reduces Inflammation in Heart Failure Patients: Clinical Findings

Objectives To investigate the mechanistic link between mitochondrial dysfunction and inflammatory activation in peripheral blood mononuclear cells (PBMCs), and the potential antiinflammatory effec...

Nicotinamide Riboside Supplementation Safely Boosts NAD+ in Middle-Aged and Older Adults: Clinical Findings

Objectives To assess the tolerability and efficacy of chronic NR supplementation on increasing NAD+ levels in healthy middle-aged and older adults. Journal Nature Communications Key Outcomes NR ...

NAD+ Metabolism and Heart Failure: Review

SynopsisNAD+, along with its reduced form NADH, is central to energy metabolism and is also the starting point for NADP+ production and a co-substrate for key enzymes that regulate oxidative stress...

NAD+ Precursors in Health, Disease, and Aging: Review

SynopsisNAD+ is an essential molecule that helps the body make energy, send signals between cells, keep mitochondria healthy, and decide whether cells survive or die. Research shows that NAD+ level...