Treatment with Bezafibrate and Nicotinamide Riboside Temporarily Stabilizes Cardiovascular Health in Complex I Deficiency: Case Report

Objectives To evaluate the effects of high-dose bezafibrate and NR administration in treating an infant with mutations in the ACAD9 gene, resulting in ACAD9-related complex I deficiency. Journal M...

Nicotinamide Riboside Protects Mitochondria and Mitigates Brain Dysfunction in Chronic Cerebral Hypoperfusion: Preclinical Findings

Synopsis Chronic cerebral hypoperfusion (CCH)—a long-term reduction in blood flow to the brain—is a major cause of vascular dementia (VaD), which leads to memory loss and cognitive decline. This s...

Effects of Intravenous Nicotinamide Riboside on Doxorubicin-Related Organ Damage: Preclinical Findings

Synopsis Doxorubicin (DOX) is a powerful chemotherapy drug used to treat various cancers, but its use is limited by serious side effects that damage vital organs such as the heart, kidneys, liver,...

Nicotinamide Riboside–Mediated Cardioprotection Depends on Insulin Signaling and Glycolytic Metabolism: Preclinical Findings

Synopsis Low levels of nicotinamide adenine dinucleotide (NAD+) contribute to heart diseases, aging, and ischemia-reperfusion injury (IRI)—the tissue damage that occurs when blood supply returns t...

Liposome Encapsulation Improves Brain Delivery and Neuroprotective Efficacy of Nicotinamide Riboside in Cerebral Ischemia: Preclinical Findings

Synopsis Although nicotinamide riboside (NR), a vitamin B3–derived NAD+ precursor, has proven neuroprotective effects, its poor ability to cross the blood–brain barrier limits its effectiveness in...

Nicotinamide Riboside Protects Against Myocardial Ischemia/Reperfusion Injury: Preclinical Findings

Synopsis Myocardial ischemia-reperfusion (I/R) injury—tissue damage caused when blood flow returns to the heart after a period of oxygen deprivation—can worsen heart attacks and lead to lasting ca...

Nicotinamide Riboside Reverses Pulmonary Hypertension: Preclinical Findings

Synopsis Pulmonary hypertension (PH) is a deadly lung vascular disease caused by endothelial dysfunction and vascular remodeling that strain the heart. This study identified Sirtuin 7 (SIRT7)—a NA...

Nicotinamide Riboside Improves Mitochondrial Function and Survival Post-Heart Attack: Preclinical Findings

SynopsisMyocardial infarction (MI), or heart attack, is a leading cause of death, and reduced NAD+ levels in the heart can worsen damage after MI. This study tested whether nicotinamide riboside (N...

Raising NAD+ via Nicotinamide Riboside Enhances Heart Function in Heart Failure: Preclinical Findings

SynopsisBoosting cellular NAD⁺ levels has been shown to prevent heart problems in various models of heart failure, but how it works at the molecular level is not fully understood. Most studies focu...

Maternal Nicotinamide Riboside Protects Against Cardiac Mitochondrial Dysfunction and Supports Fetal Growth: Preclinical Findings

SynopsisGestational hypoxia reduces fetal growth and impairs heart and placental mitochondrial function, partly by limiting NAD+ and energy production. In this study, pregnant guinea pigs were expo...

Nicotinamide Riboside and Nicotinamide Mononucleotide Prevent Oxidative Stress in Blood Vessel Cells From COVID-19 Patients: Preclinical Findings

SynopsisCOVID-19 is associated with vascular endothelial dysfunction, but mechanisms remain unclear. This study exposed human aortic endothelial cells (HAECs) to plasma from hospitalized COVID-19 p...

Interferon-β in Combination with Nicotinamide Riboside Offers Protection Against Sepsis: Preclinical Findings

Synopsis Sepsis is a severe, often fatal condition in which the body’s immune response to infection causes widespread inflammation and organ failure. This study found that combining interferon-β (...

Timing of NAD+ Precursors Determines Neuroprotection After Stroke: Preclinical Findings

Synopsis Researchers studying nicotinamide riboside (NR) and nicotinamide (NAM)—both vitamin B3-based NAD+ boosters—found that the timing of supplementation plays a critical role in brain recovery...

Intravenous Nicotinamide Riboside Protects the Heart from Chemotherapy-Induced Damage: Preclinical Findings

Synopsis Doxorubicin, a widely used chemotherapy drug, is effective against many cancers but often causes dose-dependent heart damage, leading to chronic heart failure. This study evaluated the ca...

Nicotinamide Riboside Supplementation Is Safe and Well-Tolerated in Heart Failure Patients: Clinical Findings

Objectives To assess the safety and tolerability of NR in patients with Stage C heart failure with reduced ejection fraction (HFrEF). Journal JACC: Basic to Translational Science Key Outcomes Hig...

Nicotinamide Riboside Restores NAD+ and Improves Heart and Brain Function in Leigh Syndrome: Preclinical Findings

SynopsisMice lacking the mitochondrial complex I subunit Ndufs4 develop Leigh syndrome (LS), marked by serious brain and heart problems. This study found these mice have slow, irregular heartbeats ...

CD38 Inhibitor MK-0159 Preserves NAD+ and Protects the Heart From Ischemia/Reperfusion Injury: Preclinical Findings

Synopsis The enzyme CD38 breaks down important molecules like NAD+ and NADP+, which are vital for cellular energy production and mitochondrial health. When CD38 activity increases—such as during a...

Nicotinamide Riboside Restores Memory and Protects the Brain After Stroke: Preclinical Findings

Synopsis After a stroke, the brain suffers from a sudden loss of blood flow that damages neurons and causes memory problems. This study found that treating mice with nicotinamide riboside chloride...

Nicotinamide Riboside Protects Heart Function and Survival After Circadian Disruption: Preclinical Findings

Synopsis The circadian clock, which regulates daily biological rhythms, also plays an important role in heart health. In this study, mice lacking REV-ERB receptors—key circadian regulators in the ...

Nicotinamide Riboside Improves Vascular Health and Reduces Inflammation in Atherosclerosis: Preclinical Findings

Synopsis Atherosclerosis, the buildup of plaques in arteries, begins with endothelial cell dysfunction and inflammation triggered by high cholesterol. This study found that loss of SIRT3, a mitoch...