The 14 Hallmarks of Aging: How NAD+ Plays a Role in Every Hallmark

Key Takeaways Aging is a system of biological processes, not isolated events: 14 biological and psychological/social hallmarks interact to drive the aging process. NAD+ is a central hub: A decl...

NR vs. NMN: What the Latest Human Research Actually Shows

Two newly published clinical studies tested NR and NMN head-to-head in humans for the first time. Explore what the latest clinical data reveals about which NAD+ precursor is more effective at incre...

Nicotinamide Riboside Chloride Now Has a USP Monograph—Here’s What That Means

The United States Pharmacopeia (USP) has published a compendial standard for nicotinamide riboside chloride (NRCl), making it one of the only NAD+ precursors to meet pharmacopeial quality benchmark...

What Is a Patent? Types, Uses, and Why They Matter for NAD+

Patents are the foundation of innovation, but understanding what they are and how they work is more nuanced than it may seem. This educational guide breaks down the types of patents, what each prot...

NAD+ IV Therapy vs. NR IV Therapy: What Clinical Research Reveals About Safety, Efficacy, and Why It Matters

NAD+ cannot enter cells directly, and that biological reality has major implications for NAD+ IV therapy. Two clinical studies comparing NR IV and NAD+ IV head-to-head reveal what that means in pra...

Peripheral Artery Disease and NAD+: Mitochondrial Health, Vascular Aging, and Emerging Clinical Evidence

Peripheral artery disease impacts over 200 million people globally, causing pain, reduced mobility, and increased cardiovascular risk. Emerging evidence links NAD+ to improved mitochondrial and vas...

The Role of NAD+ in Immune Health and Function

Explore how NAD+, an essential cellular molecule, supports immune health through its roles in energy production, DNA repair, and inflammation regulation. Learn how viral infections and immune stres...

NAD+ and Cancer: Current Research on Supplementation Safety and Risk

As NAD+ supplementation grows in popularity, questions about cancer risk have emerged. This article breaks down the research, highlights misleading media claims, and delves into the nuanced science...

Can NAD+ Help with Long COVID Recovery? What We Know

New research suggests that nicotinamide riboside (NR), a precursor to NAD+, may help improve long COVID symptoms like fatigue, mood, and sleep quality. Explore the science behind this potential mol...

FDA Classifies NAD+ Injection Recalls: Understanding the Safety Risks and What You Need to Know About Endotoxins and Quality

The U.S FDA has classified two recalls of NAD+ injections from GenoGenix, LLC, with the latest Class I recall linked to dangerous endotoxin contamination. Find out which products are affected, the ...

Can Increasing NAD+ Support Skin Health & Aging?

Explore how NAD+ supports skin health, why its levels decline with age, and how nicotinamide riboside (NR) may help boost NAD+ from the inside out to support healthy skin.

No Evidence Shows That Oral NAD+ Supplementation Increases NAD+ Levels in Humans

Oral NAD+ supplements have not been shown to increase NAD+ levels in humans, a conclusion recently supported by the National Advertising Division (NAD). Learn why the science shows oral NAD+ is ine...

FDA Reverses NMN Decision: Risks, Quality Concerns, and Alternative Options

The U.S. FDA reversed its previous ban on NMN supplements, yet low-quality products and patent challenges pose risks. Explore safe, more effective NAD+ precursors backed by science.

NR, NMN, & NAD+ Supplements: What Testing Reveals About Quality

Despite the booming market, most NAD+ supplements fail testing, with many NR, NMN, and NAD+ products underdosed or mislabeled. Protect your health and wallet by choosing supplements with transparen...

Why You Can't Take NAD+ Directly—and the Best Precursor to Boost NAD+ Effectively

Despite the hype, NAD+ supplements can't enter cells intact—but science shows NAD+ precursors like nicotinamide riboside (NR) efficiently cross cell membranes and are backed by over 35 clinical stu...

Research Found an Association Between Muscle Health and NAD+ Abundance in Humans

Aging results in a gradual loss of skeletal muscle function over time. Sarcopenia, the progressive loss of skeletal muscle mass, strength, and performance with age, is one of the critical causes of...

Nicotinamide Riboside Supplementation Improves Ataxia Scores and Increases Antibody Levels in Ataxia Telangiectasia Patients

Ataxia telangiectasia (AT) is a rare, inherited neurodegenerative disorder characterized by cerebellar degeneration, immunodeficiency, and cancer predisposition. Previous preclinical research has s...

Combined Metabolic Activators Therapy Reduces Liver Fat by 10% In Nonalcoholic Fatty Liver Disease Patients

A recent phase 2 clinical trial published on Cell Press Sneak Peek, a preprint publication website for papers under review by Cell Press Journals, found that a novel combined metabolic cofactor sup...

Nicotinamide Riboside Helps Protect Nerve Fibers During Chemotherapy and Enhances Paclitaxel’s Tumor-suppressing Effects in Animal Models

Raising NAD+ levels with nicotinamide riboside has been shown, in animal models, to reduce pain resulting from the cancer treating drug therapy paclitaxel. When administered to rodents in combinati...

Combined Metabolic Activators (CMAs) Improve Cognitive Functions without Altering Motor Scores in Parkinson's Disease

A new study assessing whether administration of a mixture of Combined Metabolic Activators (CMAs), including NAD+ precursor nicotinamide riboside (NR), could treat Parkinson’s disease patients, is ...