What Is Oxidative Stress? Causes, Biomarkers, and the NAD+ Connection

Oxidative stress is a fundamental biological process that sits at the intersection of mitochondrial function, inflammation, DNA repair, and aging. Learn what oxidative stress is, how researchers me...

NAD+ and Rare Diseases: The Shared Biology Behind Orphan Conditions

Expert-reviewed by Dr. Vilhelm Bohr, M.D., Ph.D., D.Sc. Key Takeaways Shared mechanism: Many genetically distinct rare diseases converge on the same downstream problems: mitochondrial failure, im...

Does NAD+ Decline with Age? Yes, But Blood NAD+ and Tissue NAD+ Are Not the Same

A newly published study reports that whole blood NAD+ does not decline with age, failing to account for well-documented tissue-specific declines. Human data from brain, muscle, skin, and liver cont...

NAD+ and Brain Health: What the Science Actually Says About Aging, Neurodegeneration, and Cognitive Function

NAD+ is one of the most important molecules in your brain, and it declines with age. From Alzheimer's and Parkinson's to mild cognitive impairment, scientists are uncovering how that decline may dr...

The 14 Hallmarks of Aging: How NAD+ Plays a Role in Every Hallmark

Key Takeaways Aging is a system of biological processes, not isolated events: 14 biological and psychological/social hallmarks interact to drive the aging process. NAD+ is a central hub: A decl...