NR, NMN, & NAD+ Supplements: What Testing Reveals About Quality

Despite the booming market, most NAD+ supplements fail testing, with many NR, NMN, and NAD+ products underdosed or mislabeled. Protect your health and wallet by choosing supplements with transparen...

Why You Can't Take NAD+ Directly—and the Best Precursor to Boost NAD+ Effectively

Despite the hype, NAD+ supplements can't enter cells intact—but science shows NAD+ precursors like nicotinamide riboside (NR) efficiently cross cell membranes and are backed by over 35 clinical stu...

Research Found an Association Between Muscle Health and NAD+ Abundance in Humans

Aging results in a gradual loss of skeletal muscle function over time. Sarcopenia, the progressive loss of skeletal muscle mass, strength, and performance with age, is one of the critical causes of...

Nicotinamide Riboside Supplementation Improves Ataxia Scores and Increases Antibody Levels in Ataxia Telangiectasia Patients

Ataxia telangiectasia (AT) is a rare, inherited neurodegenerative disorder characterized by cerebellar degeneration, immunodeficiency, and cancer predisposition. Previous preclinical research has s...

Combined Metabolic Activators Therapy Reduces Liver Fat by 10% In Nonalcoholic Fatty Liver Disease Patients

A recent phase 2 clinical trial published on Cell Press Sneak Peek, a preprint publication website for papers under review by Cell Press Journals, found that a novel combined metabolic cofactor sup...

Nicotinamide Riboside Helps Protect Nerve Fibers During Chemotherapy and Enhances Paclitaxel’s Tumor-suppressing Effects in Animal Models

Raising NAD+ levels with nicotinamide riboside has been shown, in animal models, to reduce pain resulting from the cancer treating drug therapy paclitaxel. When administered to rodents in combinati...

Combined Metabolic Activators (CMAs) Improve Cognitive Functions without Altering Motor Scores in Parkinson's Disease

A new study assessing whether administration of a mixture of Combined Metabolic Activators (CMAs), including NAD+ precursor nicotinamide riboside (NR), could treat Parkinson’s disease patients, is ...

Combined Metabolic Activators (CMAs) Improves Cognitive Functions in Alzheimer’s Disease

Results of a new phase 2 clinical study assessing whether administration of a mixture of Combined Metabolic Activators (CMAs) including NAD+ precursor nicotinamide riboside (NR) could treat Alzheim...

Phase 3 Clinical Trial Demonstrates Combined Metabolic Activators (CMAs) Accelerates Recovery in Mild-to-Moderate COVID-19

Results of a phase 3, double-blind, placebo-controlled trial assessing whether a mixture of Combined Metabolic Activators (CMAs) targeted at mitochondrial function, could improve metabolic function...

Re-Balancing NAD+ Metabolism Blunts the Impact of Telomere Dysfunction in Human Cells, Mice

A recent study published in The European Molecular Biology Organization Journal, conducted by investigators at the National Institute on Aging (NIA) and the National Cancer Institute (NCI), both di...

New Phase 2 Clinical in COVID-19 Patients Finds Hydroxychloroquine (HCQ) Plus Nutritional Protocol Including Nicotinamide Riboside Significantly Improved Recovery Time Vs. HCQ Alone

On the heels of two previously published preclinical studies investigating the effect of viral infection on NAD+ levels, new clinical research in 93 mild-to-moderate COVID-19 infected patients is n...

Elderly Patients with Heart Failure Have Lower NAD+ Levels

A new study published in Experimental Gerontology found that among 170 blood donors, elderly patients with heart failure had the lowest NAD+ levels, which suggests a role for NAD+ precursors in sup...

First-of-its-kind Agricultural Study Finds In Ovo Feeding of Nicotinamide Riboside Affects Poultry Broiler Pectoralis Major Muscle Development

A study published in Translational Animal Science finds that in ovo nicotinamide riboside (NR) injections increased chick pectoralis major (PM) muscle weight, length, width, and depth – a result wh...

All Eyes on NAD+ as Preclinical Study Demonstrates Protection Against Light-Induced Retinal Degeneration

A recent study found that raising NAD+ levels in a mouse model could protect the survival and function of retinal cells, the cells responsible for sight, against damaging UV light.

NAD+ May Modulate Inflammation in End-Stage Heart Failure Patients

Raising NAD+ levels with the precursor Nicotinamide Riboside (NR) was found to reduce markers of inflammation in the blood from a small group of Stage D heart failure (HF) patients.

Nicotinamide Riboside May Offer Unique Protection Against Endothelial Inflammation

A new study shows that while both nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) can help protect against blood-vessel inflammation by raising NAD+, NR may be the more direct and ...

Raising NAD+ With Nicotinamide Riboside Resolved Social Deficits in Autism Mouse Model

An autism model developed in male mice supplemented with nicotinamide riboside (NR) was found to have restored levels of the neurotransmitter oxytocin and improved social behavior.

Raising NAD+ Levels May Support Mitochondrial Health and Fertility in Aging

Recent studies have shown that increasing cellular nicotinamide adenine dinucleotide (NAD+) levels can restore metrics of fertility, such as oocyte (immature egg) count and health, among aging mice.

Raising NAD+ Levels With Niagen® (Nicotinamide Riboside) Inhibits Coronavirus Replication in Preclinical Cell Model

New preclinical research shared on scientific publishing website bioRxiv.org has demonstrated that increasing NAD+ levels can boost the activity of protective enzymes called PARPs and reduce corona...

Innate Immunity: The Body’s Security Force

Innate immunity is the body’s first line of defense against infection which is why this powerful security system needs all the fuel it can get. One cellular energy carrier critical to this process ...