NAD+ Metabolism: Energy Production, Signaling Pathways, and Therapeutic Potential: Review

SynopsisVitamin B3's active forms, NAD+ and NADP+, are essential for energy metabolism, cell protection, and biosynthesis. Modern research shows that fluctuations in NAD+ metabolism activate signal...

Exploring NAD+ Metabolism in Host–Pathogen Interactions: Review

SynopsisNAD+ is found in all living cells and is controlled by its production, recycling, and breakdown. It is already a drug target for diseases like cancer, neurodegeneration, and inflammation, a...

NAD+ in Aging, Metabolism, and Neurodegeneration: Review

SynopsisNAD+ is a coenzyme essential for energy production, redox reactions, and as a partner for enzymes like sirtuins and PARPs. Its levels change with age, and altering its production or usage c...

NAD+ Metabolism as a Therapeutic Target for Age-Related Metabolic Diseases: Review

SynopsisNAD+ is a central redox cofactor, but its role in activating sirtuins—a family of NAD-dependent proteins that optimize mitochondrial function—has made it a focus of longevity research. Beca...

NAD+ Metabolism in Health and Disease: Review

SynopsisNicotinamide adenine dinucleotide (NAD+) is a molecule that helps enzymes in energy reactions and is also used by other enzymes involved in DNA repair, cell signaling, and regulating cell h...