Raising NAD+ via Nicotinamide Riboside Enhances Heart Function in Heart Failure: Preclinical Findings

SynopsisBoosting cellular NAD⁺ levels has been shown to prevent heart problems in various models of heart failure, but how it works at the molecular level is not fully understood. Most studies focu...

Timing of NAD+ Precursors Determines Neuroprotection After Stroke: Preclinical Findings

Synopsis Researchers studying nicotinamide riboside (NR) and nicotinamide (NAM)—both vitamin B3-based NAD+ boosters—found that the timing of supplementation plays a critical role in brain recovery...

Nicotinamide Riboside Supplementation Is Safe and Well-Tolerated in Heart Failure Patients: Clinical Findings

Objectives To assess the safety and tolerability of NR in patients with Stage C heart failure with reduced ejection fraction (HFrEF). Journal JACC: Basic to Translational Science Key Outcomes Hig...

CD38 Inhibitor MK-0159 Preserves NAD+ and Protects the Heart From Ischemia/Reperfusion Injury: Preclinical Findings

Synopsis The enzyme CD38 breaks down important molecules like NAD+ and NADP+, which are vital for cellular energy production and mitochondrial health. When CD38 activity increases—such as during a...

Nicotinamide Riboside Protects Heart Function and Survival After Circadian Disruption: Preclinical Findings

Synopsis The circadian clock, which regulates daily biological rhythms, also plays an important role in heart health. In this study, mice lacking REV-ERB receptors—key circadian regulators in the ...

Nicotinamide Riboside Improves Vascular Health and Reduces Inflammation in Atherosclerosis: Preclinical Findings

Synopsis Atherosclerosis, the buildup of plaques in arteries, begins with endothelial cell dysfunction and inflammation triggered by high cholesterol. This study found that loss of SIRT3, a mitoch...

Increasing NAD+ with NR Protects Against Aortic Aneurysms: Preclinical Findings

Synopsis Researchers found that weakened mitochondrial function in blood vessel walls contributes to aortic aneurysms and ruptures, which can cause sudden death. In mice prone to atherosclerosis a...

Nicotinamide Riboside Restores Heart Energy and Function in Heart Failure: Preclinical Findings

Synopsis More than half of people with heart failure have a condition called heart failure with preserved ejection fraction (HFpEF), but its causes are not well understood and current treatments a...

Nicotinamide Riboside Protects Against Cardiac Hypertrophy by Reducing Inflammation and Oxidative Stress: Preclinical Findings

Synopsis Cardiac hypertrophy, a thickening of the heart muscle caused by pressure overload, can lead to heart failure. In mice, nicotinamide riboside (NR), a precursor to NAD+, reduced heart and l...

Nicotinamide Riboside Reduces Heart Damage in Presence of Fentanyl, Midazolam, and Cangrelor: Preclinical Findings

SynopsisWhen blood flow to the heart is blocked and then restored—a process called ischemia-reperfusion injury—cells can be severely damaged. Researchers tested several potential protective compoun...

Unstable NAD+ Metabolism Leads to Impaired Heart Mitochondrial Function: Preclinical Findings

SynopsisPoly(ADP-ribose) polymerase (PARP) enzymes repair DNA but use NAD+ as fuel. Excessive DNA damage in heart cell mitochondria can overactivate PARP, depleting NAD+ and impairing mitochondrial...

Nicotinamide Riboside Restores Mitochondrial Function and Improves Heart Failure with Preserved Ejection Fraction: Preclinical Findings

SynopsisHeart Failure with Preserved Ejection Fraction (HFpEF) is a serious heart condition without effective treatments. In a mouse model of HFpEF, researchers found impaired mitochondrial fatty a...

Nanocrystal Nicotinamide Riboside Improves Absorption and Protects the Heart: Preclinical Findings

Synopsis Nicotinamide riboside (NR), a vitamin B3 derivative that boosts NAD+ to support mitochondrial energy, often loses effectiveness when taken orally because it breaks down too quickly in the...

Nicotinamide Riboside Lowers Cardiometabolic Risk Factors and Cardiac Oxidative Stress: Preclinical Findings

Synopsis Nicotinamide riboside (NR), known to boost NAD levels, was tested alone and combined with calorie restriction (CR) to evaluate effects on obesity and heart health in rats fed a high-calor...

Nicotinamide Riboside Supplementation Reduces Inflammation in Heart Failure Patients: Clinical Findings

Objectives To investigate the mechanistic link between mitochondrial dysfunction and inflammatory activation in peripheral blood mononuclear cells (PBMCs), and the potential anti-inflammatory effe...

Nicotinamide Riboside Protects Against Obesity-Induced Atrial Fibrillation: Preclinical FIndings

Synopsis Aging and obesity increase the risk of atrial fibrillation (AF), a condition where the heart beats irregularly. Nicotinamide phosphoribosyltransferase (Nampt) produces NAD+, which is cruc...

Nicotinamide Riboside Improves Social Behavior and Anxiety in Autism: Preclinical Findings

Synopsis Oxytocin (OT) is essential for social recognition, memory, and emotional behaviors, and it also reduces anxiety, especially during stress. CD38 is an enzyme that produces cyclic ADP-ribos...

Nicotinamide Riboside Reverses Age-Related Circadian and Mitochondrial Decline: Preclinical Findings

Synopsis Aging disrupts sleep patterns and circadian rhythms, which are linked to metabolic diseases and lower NAD+ levels. This study shows that supplementing with the NAD+ precursor nicotinamide...

Nicotinamide Riboside Improves DNA Repair, Inflammation, and Atherosclerosis: Preclinical Findings

Synopsis Atherosclerosis, the buildup of fatty plaques in arteries, is a leading cause of heart disease. Beyond cholesterol and inflammation, new research shows that DNA damage in blood vessels al...

Nicotinamide Riboside Protects the Brain from Hypertension-Related Small Vessel Damage: Preclinical Findings

Synopsis Hypertension can cause damage to small blood vessels in the brain, leading to memory problems and white matter injury, but treatments are limited. In this study, mice with angiotensin-ind...