Article: Effects of Nicotinamide Riboside Against Kidney Injury: Preclinical Findings

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Kidney Disease Kidney Health Preclinical

Effects of Nicotinamide Riboside Against Kidney Injury: Preclinical Findings

Synopsis

Sirtuin 3 (Sirt3) is an important protein that helps regulate energy use and protect cells from stress. Researchers studied its role in contrast-induced acute kidney injury (CIAKI) using both mice and kidney cells. They found that mice lacking Sirt3 had worse kidney function, with higher blood markers of kidney damage (BUN and creatinine) and lower filtration rates. These mice also showed higher oxidative stress and increased signs of cell death. Similarly, in kidney cells where Sirt3 was blocked, protective enzymes were reduced, and harmful stress and cell death markers increased. Treatment with nicotinamide riboside (NR) helped protect kidneys in normal mice, but it did not work in mice lacking Sirt3. These results suggest that Sirt3 is essential for protecting the kidneys from injury and is required for the protective effects of NR.

Journal

Journal of Translational Medicine

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Neurological Health

Nicotinamide Riboside Restores NAD+ Levels and Improves Heart Function in Cardiomyopathy: Preclinical Findings

Synopsis Cardiomyopathy caused by mutations in the lamin A/C gene (LMNA cardiomyopathy) leads to heart muscle and electrical dysfunction, often resulting in heart failure. Currently, there is no t...

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