Counteracting CD38-Induced NAD+ Depletion Reduces Multiple Organ Fibrosis: Preclinical Findings

SynopsisSystemic sclerosis (SSc) involves fibrosis in multiple organs, but its cause is not fully understood. NAD+ decline with age and disease, often due to increased CD38 activity (an NADase), ma...

Nicotinamide Riboside Supplementation Reduces Inflammation in Heart Failure Patients: Clinical Findings

Objectives To investigate the mechanistic link between mitochondrial dysfunction and inflammatory activation in peripheral blood mononuclear cells (PBMCs), and the potential anti-inflammatory effe...

Nicotinamide Riboside Supplementation with Metabolic Cofactors Reduces Liver Fat in NAFLD Patients: Clinical Findings

Objectives To determine if combined metabolic activator supplementation (CMA) will reduce hepatic fat in nonalcoholic fatty liver disease (NAFLD) patients. Journal Molecular Systems Biology Key O...

Nicotinamide Riboside Supplementation Modestly Improves Body Composition & Sleeping Metabolic Rate: Clinical Findings

Objectives To investigate the effects of NR supplementation on insulin sensitivity, mitochondrial function, and other metabolic health parameters in overweight and obese volunteers. Journal The Am...

NAD+ Levels Control Inflammatory Responses in Immune Cells: Preclinical Findings

SynopsisNAD+ is important for cell metabolism and inflammation, but how it affects immune cells is not well understood. This study looked at how changing NAD+ levels using nicotinamide riboside (NR...

Nicotinamide Riboside Supplementation Increases Muscle NAD+ Metabolome and Reduces Inflammation: Clinical Findings

Objectives To establish whether oral NR supplementation in aged participants can increase the skeletal muscle NAD+ metabolome and if it can alter muscle mitochondrial bioenergetics. Journal Cell R...

NAD-Related Compounds Affect Immune Cell Growth and Inflammatory Response: Preclinical Findings

Synopsis Nicotinamide (NAM), nicotinamide riboside (NR), and 1-methylnicotinamide (MNA) are compounds related to NAD+ that play important roles in cell signaling, including in the immune system. S...

Maternal Nicotinamide Riboside Supplementation Supports Postpartum Recovery and Offspring Brain Health: Preclinical Findings

Synopsis Metabolic stress can disrupt the balance of NAD+ molecules in the body. Nicotinamide riboside (NR) helps restore NAD+ levels and protect against such stress. This study tested whether NAD...

The Effects of NAD+ Boosting in Mitochondrial DNA Depletion Syndrome: Preclinical Findings

Synopsis Patients with mtDNA depletion syndrome 3 (MTDPS3) often die young from liver failure due to severely reduced mitochondrial DNA. Research into treatments has been difficult because MTDPS3 ...