Host Nicotinamide Feeds Gut Microbiome to Support NAD+ Metabolism: Preclinical Findings

Synopsis

Researchers found that gut bacteria play an important role in how the body produces NAD+, a molecule that helps cells create energy and stay healthy. When we eat vitamin B3 forms like nicotinamide riboside (NR), most of it is absorbed before it reaches the gut microbes. However, some nicotinamide from the bloodstream enters the gut, where bacteria convert it into nicotinic acid, another form of vitamin B3 that the body can use to make NAD+. This process helps keep NAD+ and nicotinic acid levels steady, even without extra dietary intake. In short, the gut microbiome and the body work together to recycle nutrients and support healthy energy metabolism.

Journal

Cell Metabolism