Effects of Nicotinamide Riboside Supplementation on Nerve Fiber Protection and Axon Regeneration: Clinical Findings

Objectives To investigate whether boosting NAD+ levels through nicotinamide riboside (NR) supplementation can protect against or promote regeneration of small somatic sensory axons in human skin f...

Nicotinamide Mononucleotide and Nicotinamide Riboside Protect Against Skin Aging: Preclinical Findings

Synopsis In human skin fibroblasts subjected to oxidative and photo-aging stress, nicotinamide mononucleotide (NMN) markedly increased NAD+ levels, activated sirtuin and autophagy pathways, and im...

Natural Nicotinamide Riboside–Loaded Stem Cell Extracellular Vesicles Synergistically Combat Aging: Preclinical Findings

Synopsis This study explored the potential of small extracellular vesicles (ASC-sEVs) from adipose-derived stem cells for skin care and anti-aging. Researchers purified ASC-sEVs and analyzed their...

Nicotinamide Riboside and Resveratrol Enhance Wound Healing in Diabetic Rats: Preclinical Findings

Synopsis Diabetes impairs wound healing by disrupting autophagy and promoting apoptosis. In a type 1 diabetic rat model, systemic and topical nicotinamide riboside (NR) and resveratrol (RSV) signi...

Nicotinamide Riboside Reduces Photo-Induced Hyperpigmentation in Skin Cells: Preclinical Findings

Synopsis Ultraviolet radiation (UVR) from sunlight is a major environmental factor that causes skin damage, including sunburn, DNA damage, premature aging, and hyperpigmentation. This study explor...

Nicotinamide Riboside and Pterostilbene Prevent UVB-Induced Skin Swelling and Immune Suppression: Preclinical Findings

Synopsis Exposure to ultraviolet B (UVB) radiation can cause skin inflammation, immune suppression, and long-term risks like skin cancer. This study tested whether nicotinamide riboside (NR), a vi...

Nicotinamide Riboside and Resveratrol Promote Diabetic Wound Healing: Preclinical Findings

Synopsis Diabetic skin ulcers are difficult to treat and often lead to severe complications like infection or amputation. This study investigated how nicotinamide riboside (NR)—a vitamin B3–derive...

Stem Cell Extracellular Vesicles Loaded with Nicotinamide Riboside, NAD+, and Resveratrol Rejuvenate Skin and Prevent Photoaging: Clinical Findings

Objectives To investigate the potential synergistic effects of loading small extracellular vesicles from adipose (fat)-derived stem cells (ASC-sEVs) with NR, NAD+, and resveratrol on photoaging an...

Porcine Placental Extract Increases NAD+ and Energy in Human Skin Cells: Preclinical Findings

Synopsis Nicotinamide adenine dinucleotide (NAD+) is an important molecule that helps our cells produce energy. As we age, NAD+ levels naturally decrease in many tissues, which can contribute to a...

Nicotinamide Riboside Enhances Wound Healing and Reverses Age-Related Declines in Skin Repair: Preclinical Evidence

SynopsisThe skin repairs itself through activation and growth of keratinocyte stem cells, but aging slows this process by unclear mechanisms. This study investigated how the metabolic regulator Pgc...

Nicotinamide Riboside Improves Wound Healing in Diabetes: Preclinical Findings

Synopsis Poor wound healing is a common complication of diabetes, largely due to impaired blood vessel formation. This study found that nicotinamide riboside (NR), a vitamin B3 derivative and NAD+...