Nicotinamide Riboside Restores Exercise Capacity and Mitochondrial Function in Barth Syndrome: Preclinical Findings

SynopsisBarth syndrome, caused by tafazzin mutation, leads to mitochondrial dysfunction and severe exercise intolerance. In a Drosophila model, NR supplementation restored exercise capacity and mit...

Nicotinamide Riboside Improves Mitochondrial Function and Exercise Ability in ANT1-Deficiency: Preclinical Findings

SynopsisMitochondrial disorders are often characterized by muscle weakness and fatigue. Mutations in the heart-muscle adenine nucleotide translocator isoform 1 (ANT1) (or ANT1-deficiency) of both h...

Nicotinamide Riboside Restores NAD+ and Improves Heart and Brain Function in Leigh Syndrome: Preclinical Findings

SynopsisMice lacking the mitochondrial complex I subunit Ndufs4 develop Leigh syndrome (LS), marked by serious brain and heart problems. This study found these mice have slow, irregular heartbeats ...

Counteracting CD38-Induced NAD+ Depletion Reduces Multiple Organ Fibrosis: Preclinical Findings

SynopsisSystemic sclerosis (SSc) involves fibrosis in multiple organs, but its cause is not fully understood. NAD+ decline with age and disease, often due to increased CD38 activity (an NADase), ma...

Treatment with S-Adenosylmethionine and Nicotinamide Riboside Immune Function in Arts Syndrome: Case Report

Objectives To assess whether co-therapy with S-adenosylmethionine (SAMe) and NR could improve clinical symptoms, immune cell function, and overall well-being in a child with Arts syndrome, beyond ...

Cockayne Syndrome Proteins Maintain Mitochondrial Health Through NAD+ Signaling: Preclinical Findings

SynopsisCockayne syndrome (CS) is a rare premature aging disorder involving DNA repair defects and mitochondrial dysfunction. Across human, mouse, and nematode models, mitochondrial dysfunction was...

Increasing NAD+ with Nicotinamide Riboside Protects Neurons in Spinocerebellar Ataxia Type 7: Preclinical Findings

Synopsis Spinocerebellar ataxia type 7 (SCA7) is a genetic disorder that damages the cerebellum and impairs movement. Researchers found that in SCA7 mice, key genes controlling calcium in cerebell...

NAMPT Deficiency in Mouse Liver Cells Shows Minimal Impact on NAD+ and Mitochondrial Health: Preclinical Findings

Synopsis Supplementation with NAD+ precursors such as nicotinamide riboside (NR) has been shown to improve mitochondrial function and prevent liver fat accumulation in high-fat diet (HFD)-fed rode...

Nicotinamide Riboside Demonstrates Cardioprotective Effects by Boosting Mitochondrial Stress Response: Preclinical Findings

Synopsis The mitochondrial unfolded protein response (UPRmt) helps cells manage misfolded proteins in mitochondria to maintain function. Cardiac mitochondria are essential for contractile function...

Nicotinamide Riboside Protects Against Liver Fibrosis: Preclinical Findings

Synopsis Nicotinamide riboside (NR) boosts NAD+ levels and offers protective effects in various diseases, but its role in liver fibrosis is unclear. This study tested NR’s ability to protect again...

L-Glutamine and Nicotinamide Riboside Supplementation in Congenital Glutamine Synthetase Deficiency: Case Study

Objectives To assess the clinical and biochemical efficacy of L-glutamine and NR supplementation in a child with congenital GS deficiency. Journal Neuropediatrics Key Outcomes Treatment with L-gl...

Nicotinamide Riboside Improves Alzheimer's Features and DNA Repair: Preclinical Findings

Synopsis Alzheimer’s disease (AD) involves problems with energy metabolism and DNA repair, but how these contribute to key AD features is unclear. A DNA repair-deficient AD mouse model (3xTgAD/Pol...

A High-Fat Diet and Increasing NAD+ Rescues Premature Aging in Cockayne Syndrome: Preclinical Findings

Synopsis Cockayne syndrome (CS) is a rare genetic disorder that causes early aging and progressive brain degeneration due to problems in DNA repair genes (CSA or CSB). In mice with the CSB mutatio...

Mitochondrial Dysfunction Linked to NAD+ Decline and DNA Repair Dysfunction: Preclinical Findings

SynopsisMitochondrial problems are common in aging and neurodegenerative diseases. In xeroderma pigmentosum group A (XPA), a disease caused by faulty DNA repair that leads to severe neurodegenerati...