Article: Nicotinamide Riboside Supplementation Safely Boosts NAD+ in Middle-Aged and Older Adults: Clinical Findings

Mar 29, 2018 Cardiovascular Health Clinical Pharmacokinetic/Safety

Nicotinamide Riboside Supplementation Safely Boosts NAD+ in Middle-Aged and Older Adults: Clinical Findings

Objectives

To assess the tolerability and efficacy of chronic NR supplementation on increasing NAD+ levels in healthy middle-aged and older adults.

Journal

Nature Communications

Key Outcomes

NR supplementation significantly increased average NAD+ levels by 60% compared to placebo.
NR tended to lower blood pressure, especially in subjects with elevated blood pressure (in the stage I hypertension range).
NR also tended to decrease aortic stiffness.

Duration

6 weeks

Dose

1000 mg

Study Design

Randomized, double-blind, placebo-controlled crossover study in 30 healthy, middle-aged, and older men and women

See Published Study

Cellular Health

Therapeutic Potential of NAD-Boosting Molecules: Review

SynopsisNicotinamide adenine dinucleotide (NAD+) is best known as a hydrogen carrier in energy-producing reactions, but it also acts as a signaling molecule that controls hundreds of vital processe...

Clinical

High-Dose Nicotinamide Riboside Supplementation Is Safe and Effective: Clinical Findings

Objectives To test the safety of NR supplementation and its potential to improve insulin sensitivity and other metabolic parameters in obese, insulin-resistant men. Journal The American Journal of...