Article: Nicotinamide Riboside Supplementation Safely Boosts NAD+ in Middle-Aged and Older Adults: Clinical Findings

Cardiovascular Health Clinical Pharmacokinetic/Safety

Nicotinamide Riboside Supplementation Safely Boosts NAD+ in Middle-Aged and Older Adults: Clinical Findings

Objectives

To assess the tolerability and efficacy of chronic NR supplementation on increasing NAD+ levels in healthy middle-aged and older adults.

Journal

Nature Communications

Key Outcomes

NR supplementation significantly increased average NAD+ levels by 60% compared to placebo.
NR tended to lower blood pressure, especially in subjects with elevated blood pressure (in the stage I hypertension range).
NR also tended to decrease aortic stiffness.

Duration

6 weeks

Dose

1000 mg

Study Design

Randomized, double-blind, placebo-controlled crossover study in 30 healthy, middle-aged, and older men and women

See Published Study

Clinical

Nicotinamide Riboside Supplementation Increases Blood NAD+ Levels in Healthy Humans: Clinical Findings

Objectives To determine the human pharmacokinetics of NR supplementation and its effect on whole blood nicotinamide adenine dinucleotide (NAD+) levels. Journal PLoS ONE Key Outcomes NR supplement...