Nicotinamide Riboside and Pyruvate Increase Anti-Inflammatory Pathways: Preclinical Findings

Synopsis This study uncovered a previously unknown anti-inflammatory metabolite, homocysitaconate, produced through the interaction of homocysteine and itaconate during inflammation. The enzyme S-...

Nicotinamide Riboside Reduces T Cell Exhaustion and Improves Survival in Sepsis: Preclinical Findings

Synopsis Sepsis, a life-threatening response to infection, often causes the immune system to weaken through T cell exhaustion, leading to poor recovery and high mortality. This study found that in...

Nicotinamide Riboside Protects Against Ovarian Injury in Sepsis: Preclinical Findings

Synopsis This study examined whether nicotinamide riboside (NR), a vitamin B3–derived NAD+ booster, can protect against oxidative stress and tissue injury caused by sepsis in rats. Researchers cre...

Interferon-β in Combination with Nicotinamide Riboside Offers Protection Against Sepsis: Preclinical Findings

Synopsis Sepsis is a severe, often fatal condition in which the body’s immune response to infection causes widespread inflammation and organ failure. This study found that combining interferon-β (...

Nicotinamide Riboside Protects Organs and Improves Survival in Sepsis: Preclinical Findings

Synopsis Sepsis, a life-threatening condition caused by the body’s extreme response to infection, often leads to multiple organ failure and remains one of the top causes of death in intensive care...