The Acute Effect of Metabolic Cofactor Supplementation: A Potential Therapeutic Strategy Against Non-Alcoholic Fatty Liver Disease

Objective

To assess the tolerability and metabolic effects of combined supplementation with combined metabolic activators (CMA), L-serine, NAC, nicotinamide riboside, and L-carnitine in healthy human subjects, and predict their impact on liver fat and metabolism.

Study Design

Acute, single dose, 5-day pilot clinical study in 19 healthy, male subjects

Dose

1000 mg

A combination supplement consisting of 1g NR, 20g L-serine, 5g N-acetyl-L-cysteine, and 3g L-carnitine

Duration

5 days

Key Outcomes

  • CMA supplementation significantly decreased blood plasma levels of markers associated with increased liver fat, as well as blood plasma levels of branch chain amino acids.

  • Mathematical modeling results showed a global increase in fat metabolism, decreased glucose metabolism, and increased synthesis of NAD+, carnitine, and glutathione.

Clinical, Liver HealthANAD Staff