Nicotinamide Riboside Supplementation Alters Body Composition and Skeletal Muscle Acetylcarnitine Concentrations in Healthy Obese Humans

Objective

To investigate the effects of NR supplementation on insulin sensitivity, mitochondrial function, and other metabolic health parameters in overweight and obese volunteers.

Study Design

Randomized, double-blind, placebo-controlled, crossover study in 15 healthy, overweight, or obese, sedentary men and women

Dose

1000 mg

Duration

6 weeks

Key Outcomes

  • NR significantly increased markers of enhanced NAD+ metabolism in human skeletal muscle (e.g., NAAD and MeNam).

  • Minor beneficial changes in body composition, sleeping metabolic rate, and skeletal muscle acetyl-carnitine concentrations were found.

Clinical, Metabolic Health, Muscle HealthANAD Staff