Boosting NAD Level Suppresses Inflammatory Activation of PBMCs in Heart Failure

Objective

To investigate the mechanistic link between mitochondrial dysfunction and inflammatory activation in peripheral blood mononuclear cells (PBMCs), and the potential antiinflammatory effect of boosting NAD+ levels.

Study Design

Ex vivo and pilot clinical study in 5 Stage D heart failure patients

Dose

2000 mg

Duration

5-9 days

Key Outcomes

  • NR supplementation increased whole blood NAD+ levels and mitochondrial respiration rate of the heart failure patients’ PBMCs.

  • NR reduced the production and gene expression of proinflammatory cytokines.

  • The systemic inflammation in heart failure patients was causally linked to mitochondrial function of the PBMCs.

Clinical, Cardiovascular HealthANAD Staff