Nicotinamide Riboside Protects Against Radiation-Induced Intestinal Injury: Preclinical Findings

Synopsis Radiation-induced intestinal injury (IR) is a major complication of colorectal cancer radiotherapy. This study shows that nicotinamide riboside (NR) markedly reduces IR severity in mice, ...

Nicotinamide Riboside Protects the Intestinal Barrier From Heat Stress: Preclinical Findings

Synopsis Heat stress damages the intestinal epithelial barrier, allowing harmful substances to enter the body. This study tested whether nicotinamide riboside (NR), a NAD+ precursor, could protect...

Nicotinamide Riboside Reduces Colitis Severity in Inflammatory Bowel Disease: Preclinical Findings

Synopsis The gut microbiome produces thousands of metabolites—small molecules that influence inflammation, immunity, and disease. To better understand their roles in inflammatory bowel disease (IB...

Nicotinamide Riboside Restores Intestinal Health and Mitochondrial Function in Colitis: Preclinical Findings

SynopsisReduced levels of PGC1α, a key regulator of cellular energy, contribute to inflammatory bowel disease (IBD). In both mice with experimental colitis and humans with ulcerative colitis, NAD+ ...

Nicotinamide Riboside Prevents Gut Damage After Ischemia: Preclinical Findings

Synopsis Acute mesenteric ischaemia happens when blood flow to the intestines is blocked, which can cause tissue damage and even gangrene. This condition is rare but can be life-threatening. Besid...