Article: The Effects of NAD+ Boosting on Glucose Metabolism or Hormone Response: Clinical Findings

Clinical Metabolic Health

The Effects of NAD+ Boosting on Glucose Metabolism or Hormone Response: Clinical Findings

Objectives

To test whether NAD+ precursor supplementation with NR affects β-cell function, α-cell function, and incretin hormone secretion as well as circulating bile acid levels in humans.

Journal

The Journal of Clinical Endocrinology & Metabolism

Key Outcomes

NR supplementation did not affect fasting or post-glucose challenge concentrations of glucose, insulin, C-peptide, glucagon, GLP-1, or GIP.
β-cell function did not respond to NR intervention and no changes in circulating adipsin or bile acids were observed..

Duration

12 weeks

Dose

2000 mg

Study Design

Randomized, double-blind, placebo-controlled, parallel assignment study in 40 healthy, obese, sedentary men

See Published Study

Clinical

Nicotinamide Riboside Supplementation Increases NAD+ Levels in Humans: Clinical Findings

Objectives To evaluate the safety and efficiacy of NR supplementation in overweight, but otherwise healthy men and women. Journal Scientific Reports Key Outcomes NR supplementation significantly a...