Article: Nicotinamide Riboside and Pterostilbene Safely Elevate NAD+ Levels in Humans: Clinical Findings

Nov 24, 2017 Clinical Pharmacokinetic/Safety

Nicotinamide Riboside and Pterostilbene Safely Elevate NAD+ Levels in Humans: Clinical Findings

Objectives

To evaluate the safety, tolerability, and efficacy of nicotinamide riboside and pterostilbene (NRPT) supplementation on sustaining elevated whole-blood NAD+ levels in healthy older adults.

Journal

npj Aging and Mechanisms of Disease

Key Outcomes

NRPT supplementation was safe, well-tolerated, and significantly increased whole blood NAD+ levels.
NRPT was associated with a significant reduction in alanine aminotransferase (ALT), a marker of liver damage, although it also led to a small increase in total and LDL cholesterol.
Functional performance improved with NRPT, as evidenced by gains in the 30-second chair stand and the 6-minute walk test, suggesting that prolonged supplementation may support overall muscle health.

Duration

12 weeks

Dose

250 or 500 mg NR + 50 or 100 mg PT

Study Design

Randomized, double-blind, placebo-controlled, multi-site study in 120 healthy, older adults

See Published Study

Cellular Health

Nicotinamide Riboside Restores Mitochondrial Function in Rev1-Deficient Cells: Preclinical Findings

Synopsis DNA, which carries the genetic information of all organisms, is constantly exposed to damage from both internal and external sources. If this damage—like single- or double-strand breaks—i...

Clinical

Nicotinamide Riboside Supplementation Increases Blood NAD+ Levels in Healthy Humans: Clinical Findings

Objectives To determine the human pharmacokinetics of NR supplementation and its effect on whole blood nicotinamide adenine dinucleotide (NAD+) levels. Journal PLoS ONE Key Outcomes NR supplement...