Chronic Nicotinamide Riboside Supplementation is Well-Tolerated and Elevates NAD+ in Healthy Middle-Aged and Older Adults

Objective

To assess the tolerability and efficacy of chronic NR supplementation on increasing NAD+ levels in healthy middle-aged and older adults.

Study Design

Randomized, double-blind, placebo-controlled, crossover study in 30 healthy, middle-aged, and older men and women

Dose

1000 mg

Duration

6 weeks

Key Outcomes

  • NR supplementation significantly increased average NAD+ levels by 60% compared to placebo.

  • NR tended to lower blood pressure, especially in subjects with elevated blood pressure (in the stage I hypertension range).

  • NR also tended to decrease aortic stiffness.

Clinical, Pharmacokinetic/SafetyANAD Staff