Oral Supplementation of Nicotinamide Riboside Alters Intestinal Microbial Composition in Rats and Mice, But Not Humans
Objective
To explore the effects of NR supplementation on the gut microbiota composition in humans.
Study Design
Randomized, double-blind, placebo-controlled, parallel assignment study in 40 healthy, obese sedentary men
Dose
2000 mg
Duration
12 weeks
Key Outcomes
NR supplementation did not affect the diversity or abundance of gut bacteria in humans. However, NR increased (albeit not significantly) the ratio of Firmicutes and Proteobacteria, suggesting a potential positive effect.