Nicotinamide Riboside Supplementation is Not Associated with Altered Methylation Homeostasis in Parkinson’s Disease

Objective

To investigate the impact of NR supplementation on DNA methylation patterns in the blood cells and muscle tissues of newly diagnosed, dopaminergic treatment-naïve Parkinson's disease (PD) patients.

Study Design

Randomized, double-blind, placebo-controlled, phase I study in 29 newly diagnosed PD patients

Dose

1000 mg

Duration

30 days

Key Outcomes

  • NR supplementation had no impact on DNA methylation in PD patients, including in those with common mutations in the MTHFR gene.

  • NR also resulted in minor changes in the activity of metabolic pathways and patterns of DNA methylation. However, these changes were not harmful and did not disrupt normal DNA methylation.

Clinical, Neurological Health, MethylationANAD StaffNeurological Health, Parkinson's Disease, Methylation