Nicotinamide Riboside Supplementation Does Not Alter Whole-Body or Skeletal Muscle Metabolic Responses to a Single Bout of Endurance Exercise

Objective

To assess the effects of NR supplementation on whole-body metabolism and exercise-induced mitochondrial signaling in the skeletal muscle of healthy adults.

Study Design

Randomized, double-blind, placebo-controlled, crossover study in 8 young, healthy, recreationally active men

Dose

1000 mg

Duration

1 week

Key Outcomes

  • NR did not alter NAD-sensitive signaling pathways in skeletal muscle and did not have any effect on skeletal muscle mitochondrial respiration nor whole-body metabolism.

  • Although NR did not increase skeletal muscle NAD+ levels, it increased markers of NAD flux, demonstrating the skeletal muscle bioavailability of NR supplementation.

Clinical, Muscle HealthANAD Staff