Nicotinamide Riboside is Uniquely and Orally Bioavailable in Mice and Humans

Objective

To determine the time and dose-dependent effects of NR on blood NAD+ metabolism in humans.

Study Design

Randomized, double-blind, single dose, three-arm study in 12 healthy men and women

Dose

100 mg, 300 mg, & 1000 mg

Duration

24 hours

Key Outcomes

  • Single oral doses of NR significantly and dose-dependently increased NAD+ and related metabolites in peripheral blood mononuclear cells (PBMCs).

  • Mouse pharmacokinetic data demonstrated that NR increased NAD+ levels better than niacin (NA) and stimulated NAD+ consuming activities in the liver more than nicotinamide (NAM).

Clinical, Pharmacokinetic/SafetyANAD Staff