Long-Term Nicotinamide Riboside Use Improves Coordination and Eye Movements in Ataxia Telangiectasia

Objective

To examine the safety and efficacy of long-term NR supplementation on neuromotor function in patients with ataxia telangiectasia (AT).

Study Design

Open-label, single arm, observational intervention study in 10 patients with AT

Dose

500 mg

Duration

2 years

Key Outcomes

  • Long-term NR supplementation was safe and well tolerated, with no serious adverse events.

  • Compared to historical controls, NR supplementation significantly improved motor coordination and eye movements in AT patients.

  • This is the second clinical NR trial including children under the age of 18 and the longest NR supplementation study to date.

Clinical, Neurological Health, Ataxia TelangiectasiaANAD StaffAtaxia Telangiectasia, Neurological Health