Boosting NAD Preferentially Blunts Th17 Inflammation via Arginine Biosynthesis and Redox Control in Healthy and Psoriasis Subjects

Objective

To examine how ex-vivo NR supplementation affects adaptive immunity in CD4+ T cells extracted from healthy subjects and those with mild-moderate psoriasis, and to investigate the in vivo effects of oral NR supplementation in healthy volunteers on immune responsiveness.

Study Design

Ex Vivo: CD4+ T cells were extracted from 12 mild-moderate psoriasis patients and healthy subjects and then treated with NR

In Vivo: Randomized, double-blind, placebo-controlled, pilot study in 25 young, healthy subjects

Dose

1000 mg

Duration

1 week

Key Outcomes

Ex Vivo:

  • NAD+/NADH ratio was reduced in psoriatic T cells compared to cells from healthy subjects.
    NR treatment reduced immune responsiveness in CD4+ T cells from healthy subjects and psoriasis patients.

In Vivo:

  • NR supplementation replicated the immune-modulating effects observed with ex-vivo NR administration, resulting in a decrease in inflammatory markers while enhancing antioxidant gene expression in immune cells.

Clinical, Inflammation/Immune HealthANAD StaffImmune Health